Search for dissertations about: "diagnosis of CML"
Showing result 1 - 5 of 9 swedish dissertations containing the words diagnosis of CML.
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1. Molecular Monitoring of Chronic Myeloid Leukemia Treated with Imatinib Mesylate
Abstract : The BCR-ABL fusion gene product is a constitutively activated tyrosine kinase, which is fundamental in the pathogenesis of chronic myeloid leukemia (CML). Imatinib mesylate (imatinib, Glivec® or Gleevec®), a small molecule inhibitor of the BCR-ABL tyrosine kinase, is now the first-line treatment for all newly diagnosed chronic phase CML patients. READ MORE
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2. Comorbidity in risk and outcome of hematological malignancies
Abstract : Hematological malignancies are a group of neoplasms that originate from the bone marrow or lymphatic tissues representing close to 10% of the overall cancer burden in the world. Clinical course, prognosis and survival varies greatly from very aggressive disease requiring intensive systemic chemotherapy-based treatment to indolent forms without need of therapy at diagnosis. READ MORE
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3. Clinical and Immunological Studies in Chronic Myeloid Leukaemia
Abstract : Chronic myeloid leukaemia (CML) is characterised by the constitutively active tyrosine kinase BCR-ABL. Standard treatment with tyrosine kinase inhibitors (TKI) in the chronic phase (CP) of CML conveys excellent long-term prognosis but is associated with side effects and costs. READ MORE
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4. Flexible parametric models for cancer patient survival : loss in expectation of life and further developments
Abstract : Population-based cancer studies can contribute to a better understanding of cancer patient survival. The general aim of this thesis was to develop and apply statistical methods for population-based cancer studies to ensure understanding in this area. In any analysis setting, it is important that the statistical methods are appropriate. READ MORE
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5. Knowledge Technology Applications for Knowledge Management
Abstract : We investigate how the knowledge in knowledge technology applications for knowledge management can be represented to let the user directly manage the knowledge content of the applications.In paper I we design a representation of diagnosis knowledge that allows the user to add new components and inspect the function of the device. READ MORE