Search for dissertations about: "diaphragm function"

Showing result 1 - 5 of 24 swedish dissertations containing the words diaphragm function.

  1. 1. Intensive Care Unit Muscle Wasting : Skeletal Muscle Phenotype and Underlying Molecular Mechanisms

    Author : Sudhakar Reddy Aare; Larsson Lars; Rooyackers Olav; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acute quadriplegic myopathy; gene expression; myosin; heat shock proteins; mechanical ventilation; myostatin; sepsis; corticosteroids; diaphragm; Clinical Neurophysiology; Klinisk neurofysiologi;

    Abstract : Acute quadriplegic myopathy (AQM), or critical illness myopathy, is a common debilitating acquired disorder in critically ill intensive care unit (ICU) patients characterized by generalized muscle wasting and weakness of limb and trunk muscles. A preferential loss of the thick filament protein myosin is considered pathognomonic of this disorder, but the myosin loss is observed relatively late during the disease progression. READ MORE

  2. 2. Studies of diaphragm fatigue and dysfunction

    Author : Peter J Radell; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Diaphragm function; contractility; fatigue; oxidative metabolism; 31phosphorus nuclear magnetic spectroscopy; ultrasonography; prolonged ventilation; compound muscle action potential; myopathy; electroneurography; muscle fiber; morphology.;

    Abstract : Diaphragm fatigue and dysfunction are important components of acute and chronic respiratory pump failure. We lack knowledge about the nature of diaphragm fatigue and the pathophysiological and morphological changes that occur in the diaphragm after prolonged mechanical ventilation. This thesis studied two aspects of diaphragm function. READ MORE

  3. 3. Studies on ventilatory function in chronic neuromuscular disorders

    Author : Jan Weinberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; ventilatory dysfunction; neuromuscular disorders; diaphragm; electromyogram; power spectrum; blood gas; ventilatory mechanics; sleep; polysomnography;

    Abstract : Ventilatory dysfunction is common in neuromuscular disorders (NMD). The present studies aimed at evaluating and developing methods for diagnosis of ventilatory function in NMD. Methods included were diaphragmatic EMG (EMGdi), blood gas monitoring assessed at rest and during exercise and nocturnal respiratory and sleep parameters. READ MORE

  4. 4. Lung aeration and pulmonary gas exchange during general and epidural anaesthesia : Influenced by inspired oxygen concentration and diaphragm shape

    Author : Adrian Reber; Uppsala universitet; []
    Keywords : Medical sciences; Anesthesia: epidural; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Clinical Physiology; klinisk fysiologi;

    Abstract : Induction of general anaesthesia causes a rapid decrease in functional residual capacity, which can promote alveolar collapse (atelectasis) and airway closure in dependent lung regions. Mismatching of ventilation and perfusion (VA/Q) in the lungs is accompanied by impairment of pulmonary gas exchange. READ MORE

  5. 5. Critical illness myopathy : understanding different effects on muscle fibre function

    Author : Hannah Ogilvie; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Skeletal muscle is an essential component of the human body, being one of the most dynamic and plastic tissues. As such it can be altered by numerous confounding factors. READ MORE