Search for dissertations about: "diaxial interactions"

Found 2 swedish dissertations containing the words diaxial interactions.

2. 1. Conformationally Constrained Nucleosides : Design, Synthesis, and Biochemical Evaluation of Modified Antisense Oligonucleotides

   Author : Oommen P. Varghese; Lars Engman; Jacek Stawinski; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; chemically modified oligonucleotides; azetidine; aza-ENA-T; cyanomethylene locked; free energy of activation; diaxial interactions; chair conformation; stable duplex; human serum; snake venom phosphodiesterase; antisense agents; RNase H; Organisk kemi; Chemistry; Kemi;

   Abstract : This thesis is concerned with synthesis, structure and biochemical analysis of chemically modified oligonucleotides with potential therapeutic applications. The three types of chemical modifications described here are: (a) A North-East locked 1',2'-azetidine nucleoside (b) A North locked 2',4'-cyanomethylene bridged nucleoside and (c) A 2',4'-aza-ENA-T nucleoside. READ MORE

4. 2. Carcinogenic polycyclic aromatic hydrocarbons : theoretical, molecular, in vitro and cellular characterization of biotransformation and DNA damage

   Author : Kristian Dreij; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Polycyclic aromatic hydrocarbons (PAHs) are widespread mutagenic and carcinogenic environmental pollutants, which require metabolic activation to electrophilic intermediates and subsequent covalent binding to critical targets in DNA to elicit their biological activity. Bayand fjord-region diol epoxides (DEs) have been identified as the ultimate mutagenic and carcinogenic metabolites of PAHs. READ MORE