Search for dissertations about: "diazoxide"

Showing result 1 - 5 of 14 swedish dissertations containing the word diazoxide.

  1. 1. Pulsatile insulin release from single islets of Langerhans

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Johanna Westerlund; Uppsala universitet.; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; islets of Langerhans; insulin; ELISA; cytoplasmic calcium; oscillations; type 2 diabetes; glucose; diazoxide; potassium; tolbutamide; DNP; antimycin A; iodoacetamide; microfluorometry; fura-2; KATP channels; Cellbiologi; MEDICINE Morphology; cell biology; pathology Cell biology; MEDICIN Morfologi; cellbiologi; patologi Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : Insulin release from single islets of Langerhans is pulsatile. The secretory activities of the islets in the pancreas are coordinated resulting in plasma insulin oscillations. Nutrients amplitude-regulate the insulin pulses without influencing their frequency. READ MORE

  2. 2. Effects of over-stimulation by glucose on pancreatic beta-cell functioning : studies in vitro with diazoxide

    University dissertation from Stockholm : Karolinska Institutet, Department of Molecular Medicine

    Author : Anneli Björklund; Karolinska Institutet.; Karolinska Institutet.; [1999]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetes mellitus; diazoxide; hyperglycemia; insulin secretion; islets of Langerhans; over-stimulation;

    Abstract : Long term hyperglycemia impairs pancreatic ß-cell function. In vivo studies in rats have shown a decreased glucose-induced insulin response in the perfused pancreas after high glucose infusions. READ MORE

  3. 3. Aspects on the modulation of potassium channels in insulin-producing beta-cells

    University dissertation from Stockholm : Karolinska Institutet, Department of Molecular Medicine and Surgery

    Author : Zuheng Ma; Karolinska Institutet.; Karolinska Institutet.; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; islets of Langerhans; over-stimulation; diazoxide; exocytosis; proteasome; microarray; Kv1.1.;

    Abstract : This thesis attempts to further clarify mechanisms behind the negative effects of overstimulation and the beneficial effect of β-cell rest. For this purpose diazoxide - opener of K+-ATP channels, which reversibly inhibits glucose-induced insulin secretion, was used as a probe. READ MORE

  4. 4. The importance of immunological, genetic and clinical factors for beta cell function in childhood diabetes

    University dissertation from Stockholm : Karolinska Institutet, Department of Women's and Children's Health

    Author : Eva Örtqvist; Karolinska Institutet.; Karolinska Institutet.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type I diabetes; HLA-DQ; GAD65Ab; 1A-2Ab; ICA; GAD65 epitopeC-peptide; clinical remission; beta cell rest; diazoxide.;

    Abstract : Type I diabetes is caused by environmentally initiated, progressive autoimmune destruction of pancreatic beta cells in genetically susceptible individuals, which results in insulin deficiency and hyperglycemia. At diagnosis, about 10-20 % of beta cells remain, but after insulin therapy is started, a period with regained secretive capacity follows. READ MORE

  5. 5. Endocrine aspects of obesity and weight reduction by bariatric surgery : With special emphasis on beta cell function

    University dissertation from Stockholm : Karolinska Institutet, Department of Medicine

    Author : Marie Guldstrand; Karolinska Institutet.; Karolinska Institutet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obesity; weight reduction; b ariatric surgery; insulin; glucagon; type 2 diabetes; insulin sensitivity; HPA axis; autonomic nervous system ANS ; cognitive functions; proinsulin; GIP; GLP-1; IGFBP- 1; diazoxide;

    Abstract : Severe obesity is the most predictive acquired risk factor for the development of type 2 diabetes. Bariatric surgery induces marked weight loss and reverses the diabetic state significantly. READ MORE