Search for dissertations about: "differential gene regulation"

Showing result 1 - 5 of 120 swedish dissertations containing the words differential gene regulation.

  2. 1. Contributions to Statistical Analysis of Gene Expression Data

    Author : Anders Sjögren; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; DNA microarray; differential expression; gene regulation; variance stabilising transformation; permutation; reference gene; housekeeping gene; bootstrap; quality control QC ; quality assurance QA ; quality assessment; empirical Bayes; weighted moderated t-statistic; WAME; DNA microarray;

    Abstract : .... READ MORE

  4. 2. Hypoxic gene regulation and oncogenic pathways in neuroblastoma

    Author : Erik Fredlund; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; microarray; hypoxia; MYCN; gene expression analysis; Neuroblastoma; Myc; pathway analysis; differentiation;

    Abstract : Neuroblastoma patients show remarkable clinical heterogeneity, with courses ranging from spontaneous regression to fatal tumor progression despite intense multi-modal treatment. Previous studies have shown that hypoxia pushes neuroblastoma cells towards a more immature phenotype, which correlates to aggressive disease. READ MORE

  5. 3. Gene expression in carcinogenesis

    Author : Heléne Fischer; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : It is important to understand the processes of carcinogenesis and to find out which genes are involved . One way to study the process on a molecular basis is to identify differences in gene expression. READ MORE

  6. 4. Novel endogenous mechanisms of complement regulation - A delicate balance

    Author : Andreas Holmér; Malmö Klinisk kemi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; short leucine rich glycoprotein; factor H; C1q; age-related macular degeneration; C4b-binding protein; prion disease; prion protein; Complement regulation; C-reactive protein;

    Abstract : In this thesis, the biochemical mechanisms for complement activation by endogenous proteins are explored. The short leucine-rich repeat proteins (SLRPs) help organise extracellular matrices. We found that several SLRPs bind C1q and of these, fibromodulin and osteoadherin trigger complement. READ MORE

  7. 5. Bioinformatics studies on the mechanisms of gene regulation in vertebrates

    Author : Awaisa Ghazal; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Gene regulation implicates an important role in organismal complexity through contributing to phenotypic variation. In my thesis, I studied three diverse components of gene regulatory networks including transcription factors, DNA methylation and microRNAs to elucidate their role in vertebrates. READ MORE