Search for dissertations about: "diffferentiation"

Found 1 swedish dissertation containing the word diffferentiation.

2. 1. The role of the leukemia-associated ETO homologue repressors in hematopoiesis

   Author : André Olsson; Avdelningen för hematologi och transfusionsmedicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MTGR1; ETO; MTG16; AML1-ETO; hematopoiesis; leukemia; diffferentiation; extracellular fluids; Haematology; Medicin människa och djur ; extracellulära vätskor; Hematologi; Medicine human and vertebrates ;

   Abstract : The fusion protein AML1-ETO is observed in acute myeloid patients with the chromosomal translocation t(8;21). Cells with this chimeric protein have impaired granulocytic and erythroid differentiation with accumulation of myeloblasts. The transcriptional co-repressor ETO (Eight Twenty One) was identified from the cloning of AML1-ETO. READ MORE