Search for dissertations about: "diffuse lung disease"

Showing result 1 - 5 of 7 swedish dissertations containing the words diffuse lung disease.

  2. 1. High resolution computed tomography in smoking induced disease

    Author : Jenny Vikgren; Göteborgs universitet; []
    Keywords : Smoking induced disease; emphysema; bronchiolitis; HRCT; lung function;

    Abstract : Chronic obstructive pulmonary disease (COPD), usually caused by smoking, is common. It has high morbidity and mortality, and the prevalence is expected to increase. In Sweden about 500 000 individuals are affected, and COPD is the third most common cause of death among men. COPD is due to various combinations of small airway disease and emphysema. READ MORE

  4. 2. Systemic sclerosis : vascular, pulmonary and immunological aspects

    Author : Grethe Neumann Andersen; Solbritt Rantapää Dahlqvist; Lucia Mincheva-Nilsson; Sören Jacobsen; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic sclerosis; interstitial lung disease; MMP-9; Th1 Th2; transcription factors; NO; iNOS; E-selectin; endothelium-dependent dilation; endothelium-independent dilation.; Rheumatology; Reumatologi;

    Abstract : In systemic sclerosis (SSc), interstitial lung disease (ILD) and engagement of the vascular system lead to increased morbidity and mortality. The aim of this thesis was to elucidate, in a consecutively included cohort of SSc (limited and diffuse) patients (n = 33), the T cell cytokine profile driving the disease in ILD and to explore the role of matrix metalloproteinase 9 (MMP-9) and its inhibitor: tissue inhibitor of metalloproteinase 1 (TIMP-1) in the extracellular matrix (ECM) degrading process leading to fibrous scarring and honey combing. READ MORE

  5. 3. The role of the endothelin system in experimental acute lung injury : with special reference to the formation of extra-vascular lung water

    Author : Patrik Rossi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Acute lung injury; endothelin-1; extra-vascular lung water; pulmonary capillary pressure; sepsis; pulmonary edema; endotoxin;

    Abstract : Acute lung injury is a major clinical challenge in the intensive care unit. Sepsis is the most frequent underlying cause of this pulmonary syndrome, which contains inflammation-induced diffuse alveolar damage and early stage high permeability edema. READ MORE

  6. 4. Regulation of molecular processes in diffuse large B-cell lymphoma

    Author : Therese Högfeldt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The molecular understanding of diseases has advanced rapidly due to the use of gene expression profiling. However, these methods have been hampered by the limitation to use frozen tissue specimens. Formalin fixation and paraffin embedding (FFPE) is a standard procedure for long time storage of tissues. READ MORE

  7. 5. The expression and molecular functions of LRIG proteins in cancer and psoriasis

    Author : Terese Karlsson; Håkan Hedman; Mikael Johansson; Roger Henriksson; Kim Jensen; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LRIG1; LRIG2; LRIG3; LMO7 lung cancer; glioma; psoriasis; Oncology; onkologi;

    Abstract : The leucine-rich repeats and immunoglobulin-like domains (LRIG) family consists of three integral membrane proteins that are important in human cancer. LRIG1 is a negative regulator of growth factor signaling. Its expression is associated with longer survival in several cancer types, and the gene has been shown to function as a tumor suppressor. READ MORE