Search for dissertations about: "diketopiperazine"
Found 3 swedish dissertations containing the word diketopiperazine.
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1. Inhibition of the MDM2/p53 Interaction Design, Synthesis and Evaluation of MDM2 Inhibitors
Abstract : Numerous essential cellular processes are regulated by protein-protein interactions (PPIs) and PPIs have therefore been recognised as potential new drug targets. The transcription factor p53 is often referred to as the guardian of the genome due to its involvement in DNA repair, induction of cell cycle arrest and cellular apoptosis. READ MORE
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2. Development of an Asymmetric Synthesis of Glionitrin A and B
Abstract : In this thesis, studies in the chemical synthesis of the dithiodiketopiperazine natural products (—)-glionitrin A and B are described.In Chapter 2, a synthesis of the indoline-fused 2,5-diketopiperazine core of glionitrin A and B using a C-H activation approach is described. READ MORE
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3. Synthesis Towards Biologically Active Natural Products
Abstract : In 2005 two research groups independently reported the isolation of a series of structurally intriguing C-19 terpenolides from the plants Thapsia transtagana and Thapsia garganica. The compounds were shown to be potent inhibitors of the sarco/endoplasmic reticulum Ca2+-ATPases. READ MORE
