Search for dissertations about: "diltiazem"

Showing result 1 - 5 of 6 swedish dissertations containing the word diltiazem.

2. 1. Conctraction-mediating receptors in human peripheral vessels with special reference to veins and lymphatics

   Author : Trygve Sjöberg; Thoraxkirurgi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Human; arteries; veins; lymphatis; contraction; in vitro; in vivo; adrenergic receptors; noradrenaline; cirazoline; phenylephrine; clonidine; calcium antagonists; nifedipine; diltiazem; prostaglandins; thromboxane A2; U-46619; BM-13.505; indomethacin;

   Abstract : By means of a myograph, postjunctional alpha-adrenoceptors were characterized in human superficial epigastric arteries and veins obtained from health subjects. The rank order of potency of subtype selective agonists could not be used for receptor characterization in these vessels, whereas antagonists gave distinct results. READ MORE

4. 2. Renal dysfunction and protection in cardiovascular surgery

   Author : Anders Bergman; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Acute Renal Failure; Anesthesia; Atrial Natriuretic Peptide; Calcitonin Gene-Related Peptide; Calcium Antagonists; Diltiazem; Heart Surgery; Postoperative Renal Dysfunction; Vascular Surgery;

   Abstract : Purpose: This thesis is focused on studies of postoperative renal dysfunction (PRD), and on renal effects and possible prophylactic potentials of three vasoactive substances, calcitonin gene-related peptide (CGRP), atrial natriuretic peptide (ANP), and the calcium channel antagonist diltiazem. Methods: In paper I the medical records of 1 030 consecutive cardiothoracic surgery patients were evaluated and glomerular filtration calculated from serum creatinine levels. READ MORE

5. 3. Metabolic drug interactions in man : methodological aspects on in vivo studies

   Author : Ylva Böttiger; Karolinska Institutet; Karolinska Institutet; []
   Keywords : drug interactions; drug metabolism; cytochrome P450; therapeutic drug monitoring; omeprazole; ketoconazole; tolterodine; ropivacaine; sirolimus; diltiazem; lamotrigine; humans;

   Abstract : The aim of this thesis was to investigate methodological aspects on in vivo metabolic drug interaction studies in man. Five pharmacokinetic studies in healthy persons or patients are presented. Together, they represent a set of model studies to evaluate the occurrence of, and extent of metabolic drug interactions in vivo. READ MORE

6. 4. The relationship between reduced renal function and cardiovascular disease

   Author : Patrik Svensson; Kardiovaskulär forskning - hypertoni; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; eGFR; creatinine; cystatin C; CKD-EPI; CKD; CVD; Genetics; Blood Pressure; Hypertension;

   Abstract : This thesis examines the relationship between measures of renal function and cardiovascular disease (CVD) in patients with hypertension (the NORDIL study) and in the healthy population (Malmö Diet and Cancer Study, MDC) and whether antihypertensive treatment response and the risk of CVD is affected by genetic variation of a regulator of the renal amiloroide sensitive sodium channel (NORDIL). In study 1 we tested creatinine, estimated glomerular filtration rate (eGFR) with Cockroft-Gault (CG) and the MDRD equations and also microalbuminuria (MA) as predictors of CVD, stroke and CVD death. READ MORE

7. 5. Factors influencing outcome in patients with obstructive hypertrophic cardiomyopathy - Effects of pharmacotherapy, pacing and surgical myectomy

   Author : Davood Javidgonbadi; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hypertrophic obstructive cardiomyopathy; myectomy; pacing; beta-blocker; survival; sex; re-intervention rate;

   Abstract : Background: Most studies on risk factors for disease-related mortality in hypertrophic cardiomyopathy (HCM) have emanated from specialized tertiary centres which are subject to possible referral bias. About one quarter of HCM-patients have outflow obstruction in the left ventricle, hypertrophic obstructive cardiomyopathy (HOCM). READ MORE