Search for dissertations about: "diphtheria"

Showing result 1 - 5 of 22 swedish dissertations containing the word diphtheria.

  2. 1. Development of a New Oral Vaccine against Diphtheria and the Study of its Immunogenicity in Mouse and Man

    Author : Niclas Rydell; Ingvar Sjöholm; Sveinbjörn Gizurarson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; oral vaccination; mucosal vaccination; diphtheria; biodegradable; microparticles; starch; CRM197; adjuvant; vaccine; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

    Abstract : Most pathogens enter the body via mucosal surfaces. In contrast to parenterally administered vaccination, mucosal vaccination has the advantage of eliciting both a systemic and a local mucosal immune response. An oral biodegradable adjuvant with these features would have great potential. READ MORE

  4. 2. Vaccine responses after chemotherapy or stem cell transplantation in patients with hematological malignancies

    Author : Sigrun Einarsdottir; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vaccination; chemotherapy; stem cell transplantation; antibodies; tetanus; diphtheria; polio; Tick-borne encephalitis TBE ; SARS-CoV-2;

    Abstract : The prevention of infections in patients with hematological malignancies is important given the inherent immune deficiency associated with these diseases and the immunosuppressive effects of treatment. This thesis investigated the efficacy of vaccines against various pathogens among patients with hematological disease receiving chemotherapy or stem cell transplantation, including the longevity of vaccine responses. READ MORE

  5. 3. Functional analysis of the mouse J chain

    Author : Lena Erlandsson; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; diphtheria toxin A; plasma cell; mucosa; J chain; knock-out; serology; transplantation; Immunologi; serologi;

    Abstract : We have in this study analyzed the function of the murine Joining chain (J chain) in vivo. J chain is a polypeptide found in sera and secretions in complex with pentameric IgM and dimeric IgA. READ MORE

  6. 4. Immune reconstitution after childhood leukemia. Aspects on immunizations and effects of Ara-C on the innate immune system

    Author : Torben Ek; Göteborgs universitet; []
    Keywords : acute lymphoblastic leukemia; immune reconstitution; immunization; antibody; avidity; ara-C; fever; cytokines;

    Abstract : Children with acute lymphoblastic leukemia (ALL) can be cured with cytotoxic chemotherapy, but myelosuppression and immunosuppression are major side effects causing morbidity and even mortality from infections. Vaccinations with diphtheria toxoid (DT), tetanus toxoid (TT) and protein conjugated Haemophilus influenzae type B (Hib) capsular polysaccharide were used to investigate the adaptive immune system in a controlled study of 31 children after treatment for ALL. READ MORE

  7. 5. Costs in the ecology and evolution of the vertebrate immune system

    Author : Lars Råberg; MEMEG; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; cost of resistance; ecological immunology; immunocompetence; Parus caeruleus; transgenic mice; Animal ecology; Djurekologi; blue tit; basal metabolic rate;

    Abstract : A central assumption of theories of the ecology and evolution of immunological defence is that defence has not only benefits (in the form of resistance against parasites), but also costs. The aim of my studies was to investigate the nature and magnitude of costs of the vertebrate immune system, and to examine some of the consequences of these costs. READ MORE