Search for dissertations about: "directed evolution"
Showing result 16 - 20 of 108 swedish dissertations containing the words directed evolution.
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16. Brain morphology and behaviour in the guppy (Poecilia reticulata) : Effects of plasticity and mosaic brain evolution
Abstract : Understanding how brains have evolved and subsequently culminated in the huge variation in brain morphology among contemporary vertebrate species has fascinated researchers for many decades. It has been recognized that brain morphology is both genetically and environmentally determined. READ MORE
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17. Evolution of the subcortical circuits controlling goal-directed behaviour
Abstract : The aim of the work presented in this thesis was to reconstruct the minimal neural hardware that vertebrates use for goal-directed behaviour. By studying lamprey, one of the phylogenetically oldest vertebrates, we were able to identify the neural circuitry that has been conserved since jawed and jawless vertebrates diverged over 560 million years ago. READ MORE
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18. Directed Evolution of Glutathione Transferases Guided by Multivariate Data Analysis
Abstract : Evolution of enzymes with novel functional properties has gained much attention in recent years. Naturally evolved enzymes are adapted to work in living cells under physiological conditions, circumstances that are not always available for industrial processes calling for novel and better catalysts. READ MORE
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19. The Quest for Functional Quasi-Species in Glutathione Transferase Libraries
Abstract : Glutathione transferases (GSTs) are good candidates for investigations of enzyme evolution, due to their broad substrate specificities and structural homology. The primary role of GSTs is to act as phase II detoxifying enzymes protecting the cell from toxic compounds of both endo- and exogenous origins. READ MORE
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20. Combinatorial Protein Engineering Of Affibody Molecules Using E. Coli Display And Rational Design Of Affibody-Based Tracers For Medical Imaging
Abstract : Directed evolution is today an established strategy for generation of new affinity proteins. This thesis describes the development of a cell-display method using Escherichia coli for directed evolution of Affibody molecules. READ MORE