Search for dissertations about: "disease risk mapping"

Showing result 1 - 5 of 82 swedish dissertations containing the words disease risk mapping.

2. 1. Genomic strategies towards the dissection of human complex disease

   Author : Tesfai Emahazion; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Mapping; complex disease; polymorphism; SNP; association analysis; Alzheimer s disease; oxidative phosphorylation; apoptosis; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

   Abstract : Complex diseases are caused by the activities of many genes acting in concert with environmental factors. A major challenge facing human genetic research is to unravel the genetic factors behind complex disorders. READ MORE

4. 2. Genetic Mapping of Susceptibility Genes for Systemic Lupus Erythematosus

   Author : Bo Johanneson; Jean Pierre Hugot; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; Association analysis; Candidate gene; Complex disease; Genome scan; Linkage analysis; Mapping; Susceptibility genes; Systemic lupus erythematosus; Genetik; Genetics; Genetik; medicinsk genetik; Medical Genetics;

   Abstract : Systemic lupus erythematosus (SLE) is a complex autoimmune disease with unknown etiology. The aim of this thesis was to identify susceptibility regions through genetic mapping, using model-based linkage analysis on nuclear and extended SLE multicase families. READ MORE

5. 3. Clinical and genetical aspects of Celiac Disease

   Author : Audur Gudjonsdottir; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; celiac disease; sib-pair; screening; genome-wide scan; linkage analysis; heritability; genotypes; DQ2-negative; phenotypes; autoimmune disease;

   Abstract : Celiac disease (CD), or gluten-sensitive enteropathy, is one of the most common chronic diseases in childhood but is diagnosed in all ages. CD is a genetically driven immunological intolerance to dietary gluten. Th e treatment is a gluten-free diet. READ MORE

6. 4. Topics in Human Gene Mapping

   Author : Azra Kurbasic; Matematisk statistik; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; actuarial mathematics; Statistik; programming; Statistics; Mathematics; Naturvetenskap; Natural science; hidden Markov model; linkage analysis; Human genome; disease gene; programmering; aktuariematematik; operationsanalys; operations research; Matematik;

   Abstract : This thesis is interdisciplinary between Mathematical Statistics, Genetics, and Medicine. It mainly consists of topics in mathematical modelling of the correlation of inheritance of genes and disease in a family, a method called linkage analysis. It is organized as follows. READ MORE

7. 5. Genetic linkage and association studies in celiac disease: discoveries from whole genome analysis

   Author : Svetlana Adamovic; Göteborgs universitet; []
   Keywords : Celiac Disease; genome-wide scan; linkage; association; GWAS; complex disease; autoimmune; 5q31-33; HLA; IL2 IL21;

   Abstract : Celiac Disease (CD) or Gluten Sensitive Enteropathy (GSE) is a life-long disorder. It is characterized by inflammation in the small intestine of genetically predisposed individuals caused by inappropriate immune response to gluten, a protein enriched in some of our common grains (wheat, rye and barley). READ MORE