Search for dissertations about: "disruption and repair"

Showing result 1 - 5 of 21 swedish dissertations containing the words disruption and repair.

  2. 1. Mismatch repair deficiency in colorectal cancer : prognosis and prediction for basic treatment strategies

    Author : Ioannis Gkekas; Jan Novotny; Karin Strigård; Richard Palmqvist; Ulf Gunnarsson; Christian Sturesson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; defective mismatch repair; prognosis and prediction; Oncology; onkologi;

    Abstract : Colorectal cancer (CRC) remains a significant healthcare problem worldwide, being the third most common cancer and the fourth most frequent cause of cancer death. Environmental and dietary factors such as alcohol abuse, cigarette smoking, and genetic predisposition seem to constitute the main aetiologies. READ MORE

  4. 2. Moments of meaning – Towards an assessment of protective and risk factors for existential vulnerability among young women with mental ill-health concerns : A mixed methods project in clinical psychology of religion and existential health

    Author : Christina Lloyd; Valerie DeMarinis; Britt af Klinteberg; Wolfgang Rutz; Uppsala universitet; []
    Keywords : HUMANIORA; HUMANITIES; Clinical population; depression; anxiety; existential anxiety; internalized symptoms; crisis of meaning; inhibition of aggression; identity; meaning-making; emotion regulation; sense of coherence; self-concept; disruption and repair; high affective moments; existential worldview function; ontological security; belonging; loneliness; sacredness; death; Religionspsykologi; Psychology of Religion;

    Abstract : The present sequential mixed-methods project was conducted in the area of clinical psychology of religion and existential health. The central aim of the project was to investigate clinically relevant areas for an assessment of protective and risk factors for existential vulnerability and dysfunctional existential meaning-making in a clinical sample of young women with mental ill-health concerns. READ MORE

  5. 3. Identification of novel BRCA2-binding proteins that are essential for meiotic homologous recombination

    Author : Jingjing Zhang; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; meiosis; DSB; cancer; BRCA2; MEILB2; BRME1; HR; RAD51; DMC1; DDR;

    Abstract : Meiotic recombination is a molecular process in which the induction and repair of programmed DNA double-strand breaks (DSBs) creates genetic exchange between homologous chromosomes and thus increases genetic diversity and ensures chromosome segregation. Breast cancer susceptibility gene 2 (BRCA2) is a potent cancer suppressor and is required for DSB repair by homologous recombination (HR) in mitosis. READ MORE

  6. 4. Towards restoring intestinal health after pelvic radiotherapy - Lessons from dietary fiber intervention in a novel mouse model

    Author : Piyush Patel; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pelvic radiotherapy; Gastrointestinal symptoms;

    Abstract : Patients who have cancer in the pelvic region are at risk of developing gastrointestinal symptoms for weeks, months, or even years after receiving radiotherapy. These symptoms are triggered due to unwanted radiation-induced damage to surrounding non-cancerous tissues, resulting in the disruption of normal physiological functions. READ MORE

  7. 5. The role of gamma-tubulin in cell division and cancer

    Author : Greta Eklund; Malmö Molekylär patologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Although cancer is a heterogeneous disease, a common theme in tumor cells is the deregulation of cell division, which renders tumor progression independent of otherwise necessary internal or external growth cues. This may provide cancer cells with the ability to divide indefinitely, posing a threat to the rest of the organism. READ MORE