Search for dissertations about: "dissection"

Showing result 16 - 20 of 178 swedish dissertations containing the word dissection.

  2. 16. Genetic dissection of experimental autoimmune neuroinflammatory diseases in rats

    Author : Ingrid Dahlman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Multiple Sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system (CNS) causing neurological deficits. The disease has a complex etiology comprising multiple unidentified susceptibility genes and environmental influences. READ MORE

  4. 17. Genomic strategies towards the dissection of human complex disease

    Author : Tesfai Emahazion; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Mapping; complex disease; polymorphism; SNP; association analysis; Alzheimer s disease; oxidative phosphorylation; apoptosis; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

    Abstract : Complex diseases are caused by the activities of many genes acting in concert with environmental factors. A major challenge facing human genetic research is to unravel the genetic factors behind complex disorders. READ MORE

  5. 18. Genetic dissection of multifactorial disease models in the rat

    Author : Hong Jiao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Type 2 daibetes; Goto-Kakizaki rat; linkage analysis; quantitative trait locus; gene-gene interaction; mitochondrial sequence; parent-of-origin;

    Abstract : Type 2 diabetes (T2D) is characterized by two apparently distinct pathophysiologic defects - insulin resistance and a failure of the pancreatic Beta-cells to compensate for this resistance by appropriately increasing insulin secretion. There is strong evidence for an important role of genetics in both of these components. READ MORE

  6. 19. Molecular dissection of B-lymphocyte signalling using expression profiling

    Author : Jessica M Lindvall; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Btk; B-lymphocyte; gene expression profiling; signal transduction;

    Abstract : Gene expression profiling and bioinformatics have emerged into playing a large and diverse role in many aspects of both the clinical and molecular research. These two approaches have in this thesis work been used in combination in order to shed light to the role of Bruton's tyrosine kinase (Btk) in B-lymphocyte development and signal transduction. READ MORE

  7. 20. Chlamydophila pneumoniae in Cardiovascular Diseases : Clinical and Experimental Studies

    Author : Marie Edvinsson; Göran Friman; Eva Hjelm; Nils-Gunnar Ilbäck; Christina Nyström-Rosander; Stefan Thelin; Björn Berdal; Uppsala universitet; []
    Keywords : Communicable diseases; Chlamydophila pneumoniae; Chlamydia pneumoniae; trace elements; atherosclerosis; aortic valve stenosis; thoracic aortic aneurysm; aortic dissection; hepcidin; iron; Infektionssjukdomar;

    Abstract : Chlamydophila pneumoniae (C. pneumoniae) has been suggested as a stimulator of chronic inflammation in atherosclerosis. C. pneumoniae DNA was demonstrated in aortic biopsies in 50% of patients with stable angina pectoris or acute coronary syndrome undergoing coronary artery bypass grafting. READ MORE