Search for dissertations about: "dissertation on epilepsy"

Showing result 1 - 5 of 41 swedish dissertations containing the words dissertation on epilepsy.

  1. 1. Chemogenetics, Induced Neurons and Pluripotent Stem Cells: Towards Advanced Gene and Cell Therapies Targeting Epilepsy

    University dissertation from Department of Clinical Sciences, Lund University

    Author : Natalia Avaliani; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chemogenetics; iPS; iN; electrophysiology; gene and cell therapy; Epilepsy;

    Abstract : The complexity of the central nervous system and existence of the blood-brain barrier often causes difficulties for traditional pharmacological treatments of neurological diseases. This thesis explores the feasibility and potential for novel gene and cell therapy approaches, which hold better promise for neurological disorders, while particularly targeting epilepsy. READ MORE

  2. 2. Gene therapy for epilepsy: resculpturing synaptic transmission with neuropeptides

    University dissertation from Institutionen för kliniska vetenskaper, Lunds universitet

    Author : Andreas Toft Sörensen; Lund University.; Lunds universitet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LTP; synaptic plasticity; synaptic transmission; electrophysiology; Y5 receptor; Y2 receptor; neuropeptide Y NPY ; hippocampus; gene therapy; epilepsy; memory; activity-dependent release; volume transmission;

    Abstract : Intractable seizures and lack of effective antiepileptic drugs (AED) are severe and common conditions affecting many patients with epilepsy. Thus, there is an urgent need to develop new therapies in epilepsy. The search for novel treatments has identified several neuropeptide systems as potential targets for future therapeutic interventions. READ MORE

  3. 3. Novel approaches to explore mechanisms of epileptic seizures - optogenetic and chemogenetic manipulation of hippocampal circuitry

    University dissertation from Experimental Epilepsy Group

    Author : Fredrik Berglind; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Seizure; epileptogenesis; optogenetics; NpHR; ChR2; DREADD; hippocampus; in vivo; mouse;

    Abstract : Epilepsy comprises a family of neurological disorders characterized by recurrent seizures, which can be highly debilitating. Up to 30% of patients with temporal lobe epilepsy, the most common form of the disorder in adults, arising in the hippocampus, cannot be effectively treated by current pharmaceuticals. READ MORE

  4. 4. EPILEPSY AND CHILDHOOD AUTISM - with special reference to neuropsychiatric aspects on surgical interventions for medically intractable epilepsy

    University dissertation from Experimental Epilepsy Group

    Author : Susanna Danielsson; Göteborgs universitet.; Gothenburg University.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epilepsy; autism; epilepsy surgery; psychopathology; VNS; treatment outcome; children; cognition;

    Abstract : Epilepsy is much more common in individuals with autism than in the general population. The extent to which epilepsy influences the outcome of autism is poorly understood. Many children with medically intractable epilepsy have neurodevelopmental disorders, including autism. READ MORE

  5. 5. Histopathological and neuroimaging studies in partial epilepsy with emphasis on malformations of cortical development

    University dissertation from Göteborg

    Author : Sofia Eriksson; Göteborgs universitet.; Gothenburg University.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epilepsy; epilepsy surgery; multiple pathology; malformations of cortical development; microdysgenesis; morphometry; diffusion tensor imaging;

    Abstract : The aim of the first part of the present study was to describe the whole Göteborg epilepsy surgery series between 1987 and 1995 with respect to surgical procedures, histopathological findings and clinical correlates. We found a high proportion of malformations of cortical development (MCD) and patients with MCD were studied in further detail in the following studies. READ MORE