Search for dissertations about: "dissertation wnt β-catenin"

Showing result 1 - 5 of 6 swedish dissertations containing the words dissertation wnt β-catenin.

  2. 1. Cellular pathways and molecular regulation of hematopoietic stem cells

    Author : Kristina Anderson; Stamcellscentrum (SCC); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; β-catenin.; lineage commitment; hematopoietic stem cells; lineage priming; Wnt signaling pathway; biphenotypic cells; PAX5;

    Abstract : Hematopoietic stem cells (HSCs) are defined by their unique properties to self-renew and differentiate into all hematopoietic cell lineages. Residing in the bone marrow (BM), adult HSCs are organized in a hierarchy of cells that differ in their self-renewal and proliferative capacity. READ MORE

  4. 2. Regulation of morphogen signalling during neural patterning in the Xenopus embryo

    Author : Hooi Min Tan Grahn; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Suppressor-of-fused; Gli; β-Catenin; Neural; Xenopus; FGF; Signalling; HtrA1; RDH10; Retinol dehydrogenase; Retinoic acid; Spemann s organizer; Induction; Gradient;

    Abstract : Morphogens such as Hedghog, Wnt, FGF, and retinoic acid are important signals whose concentrations need to be tightly regulated in the vertebrate embryo to ensure body axis development and formation of the central nervous system. We first show that the intracellular cytoplasmic protein XSufu acts as a dual regulator of Hedgehog (Hh) and Wnt signals during neural induction and patterning in the Xenopus embryo. READ MORE

  5. 3. Role of ß-catenin and Leukotriene in Colon Cancer Progression

    Author : Tavga Salim; Malmö Cellpatologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LTD4; β-catenin; E-cadherin; GSK-3β; inflammation; colorectal cancer;

    Abstract : Abstract Colorectal cancer is the third most common cancer worldwide. Deregulation of Wnt/β-catenin signalling pathway is an early hallmark of colon cancer. Were nuclear accumulation of β-catenin is a marker of activated canonical Wnt/β-catenin signaling. One of the risk factors for development of colon cancer is inflammatory bowel disease. READ MORE

  6. 4. The role of WNT5A in oral squamous cell carcinoma

    Author : Zdenka Prgomet; Malmö högskola; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Cancer is one of the leading causes of death worldwide and furtherresearch into the cancer biology is required to improve treatment andsurvival. Cancer can start in all sites of the body and is characterizedby uncontrolled cell growth and capability of invading surroundingtissue and spreading to other sites of the body. READ MORE

  7. 5. Cancer and Therapy: A look into stemness and the tumour microenvironment

    Author : Carmen Rodriguez; Avdelningen för translationell cancerforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; COMP; STRIPAK; Notch; p21; oncofetal chondroitin sulfate; therapy; tumour microenvironment;

    Abstract : Therapy is the often-used treatment for cancer patients, even those that undergo resection surgery. While milestones have been surpassed throughout the decades for a number of cancer types, there are those that comprise of characteristics limiting effectiveness of treatments. READ MORE