Search for dissertations about: "dna and iron"

Showing result 1 - 5 of 46 swedish dissertations containing the words dna and iron.

2. 1. Manganese and Iron Heterodimers and Homodimers in Enzymes : Insights from Density Functional Theory

   Author : Katarina Roos; Per Siegbahn; Margareta R. A. Blomberg; Frank Neese; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Ribonucleotide reductase; manganese; iron; density functional theory; kemisk fysik; Chemical Physics;

   Abstract : The enzyme ribonucleotide reductase (RNR) catalyzes the reduction of ribonucleotides to deoxyribonucleotides, the building blocks of DNA, and is essential for all organisms. Canonical class I RNR R2 proteins use a diiron cofactor to generate a tyrosyl radical, which is required for catalysis. READ MORE

4. 2. Oxidative stress and alterations in the mammalian iron metabolism : A study on iron, inflammation, oxidative stress and neurodegeneration

   Author : Jonas Hälldin; Tiit Land; Paolo Arosio; Stockholms universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

   Abstract : Iron is essential for all living organisms, from bacteria to man for a broad variety of biological functions, including oxygen transport and DNA synthesis. However, iron can also be toxic, due to its involvement in the formation of highly reactive oxygen species through Fenton chemistry. READ MORE

5. 3. Protection of Biomolecules by Antioxidants - Mechanisms and Applications

   Author : Carl Grey; Bioteknik; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; dG; antioxidants; mass spectrometry; Analytical chemistry; Analytisk kemi; Food and drink technology; Livsmedelsteknik; Bioteknik; Biotechnology; DNA; Oxidation; Protein; Fenton reaction;

   Abstract : Reactive oxygen species (ROS) consisting of various oxygen-based free radicals as well as other reactive non-radical species produced in O2-related metabolism or through other processes are involved in the oxidation of such vital biomolecules as DNA, proteins and lipids. The types of oxidation represented here are known to cause many different diseases and disorders in human beings, such as cancer, Alzheimer's disease and ageing. READ MORE

6. 4. Chlamydophila pneumoniae in Cardiovascular Diseases : Clinical and Experimental Studies

   Author : Marie Edvinsson; Göran Friman; Eva Hjelm; Nils-Gunnar Ilbäck; Christina Nyström-Rosander; Stefan Thelin; Björn Berdal; Uppsala universitet; []
   Keywords : Communicable diseases; Chlamydophila pneumoniae; Chlamydia pneumoniae; trace elements; atherosclerosis; aortic valve stenosis; thoracic aortic aneurysm; aortic dissection; hepcidin; iron; Infektionssjukdomar;

   Abstract : Chlamydophila pneumoniae (C. pneumoniae) has been suggested as a stimulator of chronic inflammation in atherosclerosis. C. pneumoniae DNA was demonstrated in aortic biopsies in 50% of patients with stable angina pectoris or acute coronary syndrome undergoing coronary artery bypass grafting. READ MORE

7. 5. Structural Insights into the Acquisition and Storage of Iron

   Author : Ulrika Schagerlöf; Biokemi och Strukturbiologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Strukturkemi; Molecular biophysics; Molekylär biofysik; Structure chemistry; single particle; ferric reductase; human phagocyte superoxide-generating NADPH oxidase; frataxin; cryo electron microscopy; FRO2; iron homeostasis; iron acquisition;

   Abstract : It is of vital importance to understand the systems for iron metabolism and this thesis contributes to this by providing insights into the structure and function of the acquisition and homeostasis of iron. The two proteins that have been primarily investigated are a ferric reductase from Arabidopsis thaliana called FRO2 and a mitochondrial iron chaperone from Saccharomyces cerevisiae called frataxin. READ MORE