Search for dissertations about: "dna damages"

Showing result 16 - 20 of 24 swedish dissertations containing the words dna damages.

  2. 16. An X-ray Based Spectroscopic Study of Structure Influencing Electrons : Fragmentation, Ultrafast Charge Dynamics and Surface Composition

    Author : Geethanjali Gopakumar; Olle Björneholm; Carl Caleman; Isaak Unger; Ruth Signorell; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Fragmentation; ICD; ETMD; Ultrafast electron dynamics; Surface propensity;

    Abstract : The structure of biomolecules, such as proteins, is intimately connected to the function of the molecules. These structures are often studied using X-ray diffraction. However, the interaction of the X-ray photons with the molecule can excite or ionize its electrons which in turn can causes changes in the molecular structure. READ MORE

  4. 17. Response mechanisms of normal hematopoietic cells and leukemic cells to genotoxic agents and novel therapeutic strategies

    Author : Andreas Hedblom; Malmö Experimentell cancerforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic stem cells; genotoxic damage; cell cycle; leukemia; heme oxygenase; differentiation;

    Abstract : Hematopoiesis is initiated by a rare population of hematopoietic stem cells (HSC) in the bone marrow (BM). HSCs give rise to red blood cells and white blood cells of myeloid and lymphoid lineages. READ MORE

  5. 18. Protons, other Light Ions, and 60Co Photons : Study of Energy Deposit Clustering via Track Structure Simulations

    Author : Gloria Bäckström; Anders Ahnesjö; Nina Tilly; José M. Fernández-Varea; Niels Bassler; Uppsala universitet; []
    Keywords : Proton; light ion; Co-60 photon; track structure Monte Carlo code; clustering patterns of energy deposit; RBE; Medicinsk radiofysik; Medical Radiophysics;

    Abstract : Radiotherapy aims to sterilize cancer cells through ionization induced damages to their DNA whilst trying to reduce dose burdens to healthy tissues. This can be achieved to a certain extent by optimizing the choice of radiation to treat the patient, i.e. the types of particles and their energy based on their specific interaction patterns. READ MORE

  6. 19. Realistic tissue dosimetry models using Monte Carlo simulations. Applications for radionuclide therapies

    Author : Erik Larsson; Lund Medicinsk strålningsfysik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; internal dosimetry; radionuclide therapy; Monte Carlo; small scale dosimetry;

    Abstract : Radionuclide therapy (RNT) is a generic term for treatment modalities that use a radionuclide labeled to a target-specific molecule. This so-called radiopharmaceutical accumulates in the target, where the ionizing radiation damages the cells. At sufficient levels of radiation, the cells cannot repair themselves. READ MORE

  7. 20. Small-Scale Dosimetry for the Testis: Applications in Nuclear Medicine Diagnostics and Therapy

    Author : Suaad Meerkhan; Lund Medicinsk strålningsfysik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Testis; 111-In; Autoradiography; Biodistribution; Small-Scale; Monte Carlo; Dosimetry; spermatogonia; gammaH2AX; immunofluorescence;

    Abstract : It is well known that the testicles are among the most radiosensitive tissue, and constitute an important critical target for both external and internal radiation during diagnostic and therapeutic use of radionuclides. In systemic radionuclide therapy where very high activities are administered, the testis may become a dose-limiting organ; often with a complex, non-uniform activity distribution and a resulting non-uniform absorbed-dose distribution. READ MORE