Search for dissertations about: "dna markers"

Showing result 21 - 25 of 344 swedish dissertations containing the words dna markers.

2. 21. Quantitative detection of bacterial DNA in whole blood in bloodstream infection

   Author : Ingrid Ziegler; Kristoffer Strålin; Paula Mölling; Magnus Rasmussen; Örebro universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bloodstream infection; bacteremia; sepsis; DNA load; quantitative PCR; droplet digital PCR; 16S rDNA;

   Abstract : This thesis aims to increase the knowledge on how quantitative PCR can be used in the diagnostics of bloodstream infections, with an emphasis on quantitative elements.In Papers I and II, we evaluated quantitative data from two commercial PCR tests for pathogen detection directly in blood, Magicplex Sepsis (I) and SeptiFast (II), from patients with suspected sepsis. READ MORE

4. 22. DNA Damage Response of Normal Epidermis in the Clinical Setting of Fractionated Radiotherapy : Evidence of a preserved low-dose hypersensitivity response

   Author : Fredrik Qvarnström; Ingela Turesson; Gunilla Enblad; Mats Harms-Ringdahl; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA damage response; low-dose hypersensitivity; dose response; normal tissue; epidermis; keratinocyte; fractionated radiotherapy; DNA double strand break; DSB; foci; γH2AX; 53BP1; checkpoint; p21; apoptosis; mitosis; Oncology; Onkologi; Oncology; onkologi;

   Abstract : Investigations of DNA damage response (DDR) mechanisms in normal tissues have implications for both cancer prevention and treatments. The accumulating knowledge about protein function and molecular markers makes it possible to directly trace and interpret cellular DDR in a tissue context. READ MORE

5. 23. Computational statistical methods for genotyping biallelic DNA markers from pooled experiments

   Author : Camille Clouard; Carl Nettelblad; Lars Rönnegård; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

   Abstract : The information conveyed by genetic markers such as Single Nucleotide Polymorphisms (SNPs) has been widely used in biomedical research for studying human diseases, but also increasingly in agriculture by plant and animal breeders for selection purposes. Specific identified markers can act as a genetic signature that is correlated to certain characteristics in a living organism, e. READ MORE

6. 24. Novel Endpoints To Unravel Developmental Neurotoxicity : From DNA methylation responses to methylmercury to the in vitro identification of endocrine disruptors

   Author : Andrea Cediel-Ulloa; Joëlle Rüegg; Pamela J. Lein; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Developmental neurotoxicity; Methylmercury; DNA methylation; Endocrine disruptors; in vitro assay development; Biology with specialization in Environmental Toxicology; Biologi med inriktning mot miljötoxikologi;

   Abstract : The developing brain is especially sensitive to environmental stressors due to its dependence on the precise spatiotemporal regulation of multiple signals, and the long time period required for its formation. Some chemicals can interfere with molecular and cellular processes driving brain development, including epigenetic processes such as DNA methylation. READ MORE

7. 25. DNA content, proliferation markers and histopathology as prognostic factors in Astrocytic tumours

   Author : Ludek Vavruch; Linköpings universitet; []
   Keywords : MEDICINE; MEDICIN;

   Abstract : The DNA index and S-phase fractions obtained from freshly frozen and paraffin-embedded specimens of 49 primary intracranial tumors showed significant correlation. Very similar results were obtained when a subgroup of astrocytomas was analyzed. READ MORE