Search for dissertations about: "dna-damaging agents"

Showing result 1 - 5 of 23 swedish dissertations containing the words dna-damaging agents.

  2. 1. Measurement of sensitivity to DNA damaging agents

    Author : Sherin T Mathew; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; intrinsic sensitivity; DNA damage; ionizing radiation; cell division;

    Abstract : There is a large inter-individual variation in intrinsic sensitivity in patients receiving treatment with DNA damaging agents. Cancer therapy exemplifies this problem where patients experience varying degree of normal tissue side effects in response to radiation or chemotherapy. READ MORE

  4. 2. Chemically Induced DNA Damage in Extended-term Cultures of Human Lymphocytes

    Author : Maria Andersson; Björn Hellman; Leif Busk; Uppsala universitet; []
    Keywords : Toxicology; Comet assay; DNA-damaging agents; DNA repair; Extended-term Cultures of Human Lymphocytes; Genotoxicity; Induced DNA damage; In vitro; Mouse Lymphoma Cells; Primary Cell Cultures; Reactive Oxygen Species; Toxikologi;

    Abstract : Generation of DNA damage is regarded to be an important initial event in the development cancer. Consequently, a battery of tests have been developed to detect different types of genotoxic effects in order to be able to predict the potential genotoxicity and mutagenicity of chemicals, including both pharmaceutical drugs and various types of environmental and occupational agents, as well as dietary factors. READ MORE

  5. 3. Molecular characterization of phenothiazines in experimental cancer therapy : new tricks of an old drug revealed

    Author : Dali Zong; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cancer is characterized by uncontrolled malignant proliferation of cells that eventually interfere with tissue/organ functions. Traditionally, cancer is treated with chemo- and/or radiotherapy when surgery is not an option. Unfortunately, the efficacy of conventional anti-cancer chemotherapy is severely limited by therapy resistance. READ MORE

  6. 4. Proteomic analysis of DNA damage induced stress signaling with focus on p53 : S100A6 regulation, function and potential as biomarker in lung cancer and as a novel therapeutic target

    Author : Lukas Orre; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In this thesis powerful proteomics methods were used to reveal novel proteins involved in the cellular response to DNA damaging treatment. The goal was to find proteins with potential as biomarkers for prediction of cancer prognosis and response to cancer therapy, but also to find potential novel targets of cancer therapy. READ MORE

  7. 5. Systematic Modular Approaches to Reveal DNA Damage Responses in Mammalian Cells

    Author : J. Peter Svensson; Ingela Turesson; Jean Bourhis; Uppsala universitet; []
    Keywords : Molecular biology; gene expression profiling; DNA damage; network; cancer; ionizing radiation; cisplatin; Molekylärbiologi;

    Abstract : Cancer therapy operates by inflicting damage in malignant cells. The most lethal target is the genomic DNA. As a single double strand DNA break has the potential to kill the cell, mechanisms have evolved to detect and block propagation of the damage. READ MORE