Search for dissertations about: "doctoral thesis of diabetes"

Showing result 11 - 15 of 1679 swedish dissertations containing the words doctoral thesis of diabetes.

  1. 11. Pharmacometrics Modelling in Type 2 Diabetes Mellitus Implications on Study Design and Diabetes Disease Progression

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Siti Maisharah Sheikh Ghadzi; Maria C. Kjellsson; Mats O. Karlsson; Sandra Visser; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometric; type 2 diabetes mellitus; impaired glucose tolerance; prediabetes; anti-diabetes drug development; insulin; glucose; natural diabetes disease progression; lifestyle intervention; short-term provocation; long-term effect; glucose homeostasis; glucose and insulin regulation; weight; dropout; Pharmaceutical Science; Farmaceutisk vetenskap; Endokrinologi och Diabetologi; Endocrinology and Diabetology;

    Abstract : Pharmacometric modelling is widely used in many aspects related to type 2 diabetes mellitus (T2DM), for instance in the anti-diabetes drug development, and in quantifying the disease progression of T2DM.The aim of this thesis were to improve the design of early phase anti-diabetes drug development studies with the focus on the power to identify mechanism of drug action (MoA), and to characterize and quantify the progression from prediabetes to overt diabetes, both the natural progression and the progression with diet and exercise interventions, using pharmacometrics modelling. READ MORE

  2. 12. Dissecting the role of micro-RNAs in diabetes

    University dissertation from Department of Clinical Sciences, Lund University

    Author : Caroline Bolmeson; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Type 2 diabetes; micro-RNA; Dicer; beta-cell function; insulin secretion; glucose; NOD mouse; Goto-Kakizaki rat; human islets; thymocytes; apoptosis;

    Abstract : The role of miRNAs in pancreatic islets and β-cell function and in the development of diabetes in human and rodents have been investigated in this thesis. Dicer1 was specifically deleted in vivo in pancreatic β-cells under the RIP-promoter in mice. READ MORE

  3. 13. Epidemiological Aspects on Assessing and Treating Dyslipidemia in Type 1 Diabetes Studies from the Swedish National Diabetes Register

    University dissertation from Göteborgs universitet

    Author : Christel Hero; Göteborgs universitet.; Gothenburg University.; [2020]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; dyslipidemia;

    Abstract : Background: Cardiovascular disease (CVD) is a major cause of shortened longevity in individuals with type 1 diabetes. Dyslipidemia is one of the important modifiable risk factors. Aims: To investigate different aspects of dyslipidemia in type 1 diabetes. READ MORE

  4. 14. Congenital Heart Disease, Type 1 and Type 2 Diabetes Mellitus

    University dissertation from Göteborgs universitet

    Author : Anna Björk; Göteborgs universitet.; Gothenburg University.; [2020]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Congenital Heart Disease; Diabetes Mellitus; Type 1 Diabetes Mellitus; Type 2 Diabetes Mellitus; Mortality; Morbidity;

    Abstract : Worldwide, 1% of all live born children are born with a congenital heart disease (CHD) and currently >95% reach adulthood due to better diagnostics and medical care. At the same time, Diabetes Mellitus (DM), type 1 (T1DM) and type 2 (T2DM), is increasing worldwide. READ MORE

  5. 15. Molecular mechanisms of insulin resistance with special emphasis on IRS-1 and PKB/Akt

    University dissertation from Göteborg

    Author : Eugénia Carvalho; Göteborgs universitet.; Gothenburg University.; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Insulin; insulin resistance; diabetes; protein kinase B; insulin receptor substrate-1; insulin signalin; Glute-4; PI 3-kinase; glucose transport; adipose tissue;

    Abstract : .... READ MORE