Search for dissertations about: "dog leukocyte antigen"
Found 3 swedish dissertations containing the words dog leukocyte antigen.
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1. Genetic Studies of Immunological Diseases in Dogs and Humans
Abstract : This thesis presents genetic studies aiming at enlarging our knowledge regarding the genetic factors underlying two immune-mediated diseases, hypothyroidism and autoimmune Addison’s disease (AAD), in dogs and humans, respectively.Genetic and environmental factors are indicated to contribute to canine hypothyroidism, which can be considered a model for human Hashimoto’s thyroiditis (HT). READ MORE
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2. Evolution of MHC Genes and MHC Gene Expression
Abstract : Polymorphism in coding regions and regions controlling gene expression is the major determinant of adaptive differences in natural populations. Genes of the major histocompatibility complex (MHC) possess a high level of genetic variation, which is maintained by selection over long coalescence times. READ MORE
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3. Discovery of a novel pathway for an SLE-related disease complex in the canine breed Nova Scotia duck tolling retriever
Abstract : The dog is an excellent model to study inherited complex diseases, due to its unique population history and haplotype structure. In this thesis, dogs from the breed Nova Scotia duck tolling retriever (NSDTR) have been used as a model for defining the genetic factors controlling a systemic lupus erythematosus (SLE)-related disorder called immune-mediated rheumatic disease (IMRD) and a steroid responsive meningitis-arteritis (SRMA). READ MORE