Search for dissertations about: "dopamine neurones"

Showing result 1 - 5 of 6 swedish dissertations containing the words dopamine neurones.

2. 1. Dopamine and the regulation of movements - significance of nigral and striatal dopamine release in normal, hemiparkinsonian and dyskinetic rats

   Author : Daniel Andersson; Göteborgs universitet; []
   Keywords : dopamine; substantia nigra; striatum; L-DOPA; dyskinesias; serotonin;

   Abstract : Introduction: The nigrostriatal dopamine (DA) containing neurones are a pivotal component in the basal ganglia, a network that regulates movement. Degeneration of these neurones causes the cardinal symptoms of Parkinson’s disease (PD). READ MORE

4. 2. Cytochrome P450 2E1 - relevance for central dopamine neurotransmission and Parkinson's disease

   Author : Haydeh Niazi Shahabi; Göteborgs universitet; []
   Keywords : cytochrome P450 2E1; dopamine; substantia nigra; polymorphism; alternative splicing;

   Abstract : Introduction: The enzyme cytochrome P450 2E1 (CYP2E1) has been found in dopamine (DA) containing brain regions that are of relevance for Parkinson?s disease (PD), and is known to generate reactive oxygen species (ROS), toxic molecules that have been implicated in the degeneration of DA neurones. In addition, previous investigations have indicated that inhibition of CYP2E1 increases extracellular DA in the substantia nigra, a nucleus which degenerates in PD. READ MORE

5. 3. Apoptosis And Excitotoxicity In The Death of Cultured And Grafted Dopaminergic Neurones

   Author : Gabriele Schierle; Institutionen för experimentell medicinsk vetenskap; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ac-YVAD-cmk; MK-801; flunarizine; N-methyl-D-aspartate; voltage-dependent calcium channels; Bcl-2; caspase; excitotoxicity; apoptosis; tyrosine hydroxylase; dopamine; Parkinson s disease; intracerebral transplantation; Poly ADP-ribose polymerase; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

   Abstract : Over the past two decades, grafting of embryonic nigral tissue has developed into a feasible therapeutic strategy for Parkinson's disease (PD). It has become apparent that the degree of restoration of dopaminergic neurotransmission by the transplanted cells is highly correlated to the symptomatic relief. READ MORE

6. 4. Survival of Cultured and Grafted Embryonic Dopaminergic Neurones - Effects of hypothermia and prevention of oxidative stress

   Author : Jenny Karlsson; Neurobiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; 6-OHDA; lazaroid; PBN; brain; transplant; Parkinson s disease; dopamine; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

   Abstract : Transplantation of embryonic dopaminergic neurones can ameliorate symptoms in Parkinson’s disease, but a major obstacle for clinical transplantations to overcome is the low survival (typically 5-10%) of implanted nigral neurones. If cell death in nigral grafts can be prevented, less embryonic tissue would be needed per transplantation session and hence more patients could receive intracerebral grafts as a therapy for Parkinson’s disease. READ MORE

7. 5. Afferent input to midbrain dopamine neurones and its modulation : an electrophysiological study i vitro

   Author : Pernilla Grillner; Karolinska Institutet; Karolinska Institutet; []
   Keywords : dopamine neurones; synaptic transmission; NMDA receptors; L-type Ca2 channels; presynaptic inhibition; metabotropic glutamate receptors; muscarine; nicotine;

   Abstract : Dopamine (DA) neurones of the ventral mesencephalon are involved in the control of reward related behaviour, cognitive functions and motor performances, and provide a critical site of action for major categories of neuropsychiatric drugs, such as antipsychotic agents, dependence producing drugs and anti-Parkinson medication. The midbrain DA neurones are mainly located in the substantia nigra pars compacta (SNPC) and the ventral tegmental area (VTA). READ MORE