Search for dissertations about: "dopamine receptors DRD2"

Found 4 swedish dissertations containing the words dopamine receptors DRD2.

  2. 1. Attention-deficit/hyperactivity disorder : alterations of motor behaviour and dopaminergic transmission

    Author : Aurelija Jucaite; Karolinska Institutet; Karolinska Institutet; []
    Keywords : AD HD; DCD; neurodevelopmental disorder; PET; dopamine transporter; dopamine D2 receptors; raclopride; striatum; midbrain; anticipatory postural adjustments;

    Abstract : Altered catecholaminergic neurotransmission in the brain has long been thought to be of importance in the regulation of motor behavior and cognitive performance in children who had symptoms of distractability, impulsivity and clumsiness. The dopamine theory of AD/HD has mainly been substantiated by: i) the effects of psychostimulants, which target the dopamine transporter (DAT), and thereby reduce impulsiveness and inattentiveness, increase the striatal cerebral blood flow and functional activity, and ii) the evidence from linkage studies associating the AD/HD syndrome with allelic variations of genes encoding the dopamine transporter and, possibly, the dopamine D4 receptors. READ MORE

  4. 2. Genes that modulate or mediate dopaminergic neurotransmission : expression of the human prodynorphin gene and association studies with candidate genes in an alcohol patient sample

    Author : Thomas Geijer; Karolinska Institutet; Karolinska Institutet; []
    Keywords : association study; alcoholism; DNA polymorphisms; dopamine receptors DRD2; DRD3; DRD4 ; tyrosine hydroxylase TH ; prodynorphin; messengerRNA; gene expression; promotor Stockholm 1997;

    Abstract : The development of alcoholism may at least partly be attributed to the effect of ethanol on reward and reinforcement. As a genetic influence in the vulnerability to alcoholism and drug abuse has been documented, it is of interest to investigate genes active in brain structures which mediate reward and reinforcement. READ MORE

  5. 3. Genetic aspects on schizophrenia and cerebrospinal fluid monoamine metabolites : focus on association studies with candidate genes

    Author : Erik Jönsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : association study; schizophrenia; DNA polymorphisms; dopamine receptors DRD2; DRD3; DRD4 ; tyrosine hydroxylase; tryptophan hydroxylase; catechol-O-methyltransferase; neurotrophin-3; ciliary neurotrophic factor; healthy subjects; cerebrospinal fluid;

    Abstract : Schizophrenia is a syndrome with psychotic symptoms. The pathogenesis of schizophrenia most likely reflects brain abnormalities and heritable components are present. The principal objective of the present thesis was to investigate some possible genetic influences in the genesis or pathophysiology of schizophrenia. READ MORE

  6. 4. Molecular mechanisms underlying the actions of psychoactive drugs in the basal ganglia : focus on cannabinoids and morphine

    Author : Anders Borgkvist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : This thesis is centered on the identification of the molecular mechanisms involved in the psychomotor effects of cannabinoids and morphine. These drugs share the ability of acting at the level of the basal ganglia, a group of subcortical structures involved in the control of locomotion, as well as in cognitive and motivational aspects of motor function. READ MORE