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Showing result 1 - 5 of 122 swedish dissertations matching the above criteria.
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1. Cyanide and central nervous system : a study with focus on brain dopamine
Abstract : The brain is a major target site in acute cyanide intoxication, as indicated by several symptoms and signs. Cyanide inhibits the enzyme cytochrome oxidase. This inhibition causes impaired oxygen utilization in all cells affected, severe metabolic acidosis and inhibited production of energy. READ MORE
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2. Functional consequences of dopaminergic degeneration : Clinical and experimental studies using a novel stabilizer of dopaminergic systems
Abstract : Since the introduction of levodopa for the treatment of Parkinson's disease (PD) 30 yearsago, the emergence of motor complications, such as levodopa-induced dyskinesias (LID), hasbeen a major clinical problem in advanced stages of the disease. Clinical and preclinical studieshave revealed a number of functional changes in the dopaminergic system that may be ofimportance for the emergence of LIDs. READ MORE
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3. Generation of Dopaminergic Neurons from Human Embryonic Stem Cells
Abstract : Since the first successful derivation of human embryonic stem cells (hESC), rapid progress has been attained in the development of strategies in differentiation of these cells into various neural lineages, with the fundamental objective of using these cells for replacement and repair of damaged neuronal circuits in the central nervous system (CNS). Of particular interest are midbrain dopaminergic (mDA) neurons, which play a central role in regulation of voluntary movement. READ MORE
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4. Functional regulation of the dopaminergic system in vivo : Experimental and clinical studies with positron emission tomography
Abstract : Positron emission tomography (PET) is a non-invasive imaging technique used to quantitate the kinetics of a radiotracer in such physiological processes as receptor binding and enzyme activity. Radiolabelled L-DOPA has previously been used as a tracer for the dopaminergic system. READ MORE
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5. Functional and Transcriptional Studies of Human Dopaminergic Neurons
Abstract : Parkinson’s Disease (PD) is the most common movement disorder and second most common neurodegenerative disease. The principal hallmark of the pathology is represented by a loss of mesencephalic Dopaminergic neurons (mesDA) that reside in the Substantia Nigra pars compacta (SNpc). READ MORE