Search for dissertations about: "dopaminergic system"

Showing result 6 - 10 of 122 swedish dissertations containing the words dopaminergic system.

  2. 6. Dysfunction in the nigrostriatal system : effects of L-DOPA and GDNF

    Author : Nina Nevalainen; Ingrid Strömberg; Nancy Zahniser; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s disease; L-DOPA; dyskinesia; GDNF; dopamine; glutamate; serotonin; medicinsk utvecklings- och neurobiologi; Developmental Neurosciences;

    Abstract : Parkinson’s disease is a common neurodegenerative disorder caused by nigrostriatal dopamine loss, with motor deficiencies as the primary outcome. To increase the striatal dopamine content, patients are treated with 3,4-dihydroxyphenyl-l-alanine (l-DOPA). READ MORE

  4. 7. Synthesis, Pharmacological Characterization and QSAR Modelling of 4-Phenylpiperidines and 4-Phenylpiperazines Effects on the dopaminergic neurotransmission in vivo

    Author : Fredrik Pettersson; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; dopamine; D2; monoamine oxidase; DOPAC; in vivo; QSAR; dopaminergic stabilizer;

    Abstract : The endogenous neurotransmitter dopamine (DA) is involved in several functions that are controlled from the central nervous system (CNS), for example behaviour, memory, cognition and reward. A disturbed dopaminergic neurotransmission may lead to many severe conditions, such as schizophrenia, attention deficit hyperactivity disorder (ADHD) or Parkinson's disease (PD). READ MORE

  5. 8. Characterization of human dopaminergic neurons in the developing mesencephalon and upon differentiation of stem cells- for replacement therapy in Parkinson´s disease

    Author : Jenny Nelander Wahlestedt; Utvecklings- och regenerativ neurobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson´s disease; stem cells; ventral mesencephalon; dopaminergic neurons; cell replacement therapy; human fetal tissue; radial glia; microRNA; BAC recombineering; reporter cell lines;

    Abstract : Cell-replacement therapy is a promising approach for treating patients with Parkinson ́s disease (PD). For this purpose, there is a need for developing a protocol that can generate high numbers of human transplantable mesencephalic dopaminer- gic (mesDA) neurons. READ MORE

  6. 9. Towards cell replacement therapy in Parkinson’s disease. Proteoglycans and Nogo-A as modulators of axonal growth in midbrain dopaminergic neurons

    Author : Zuzanna Kurowska; Neural plasticitet och reparation; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LUHMES cells; substantia nigra pars compacta; microarray; heparan sulphate 3-O-sulfotransferase; neurocan; midbrain dopaminergic neurons; grafting; embryonic stem cells; proteoglycans; glycosaminoglycans; Nogo-A; cell replacement therapy; Parkinson’s disease;

    Abstract : Parkinson’s disease (PD) is currently the second most common neurodegenerative disorder (after Alzheimer’s disease). PD is diagnosed on its motor symptoms, which include akinesia, bradykinesia, rigidity, postural imbalance and resting tremor. It is well established that the motor symptoms develop due to lack of dopamine in the striatum. READ MORE

  7. 10. Lineages and molecular heterogeneity in the developing nervous system

    Author : Gioele La Manno; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Information in the genome unfolds through a dynamic process leading to the molecular and anatomical organization of a physiologically functional organism. The nervous system is the most diverse and intricate architecture generated by this process. READ MORE