Search for dissertations about: "dopaminergic"

Showing result 1 - 5 of 226 swedish dissertations containing the word dopaminergic.

  1. 1. Functional consequences of dopaminergic degeneration : Clinical and experimental studies using a novel stabilizer of dopaminergic systems

    Author : Anna Ekesbo; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Parkinson s disease; positron emission tomography; 6-OHDA; MPTP; dyskinesia; dopaminergic degeneration; - -OSU6162; Neurovetenskap; Neurology; Neurologi; Neurology; neurologi;

    Abstract : Since the introduction of levodopa for the treatment of Parkinson's disease (PD) 30 yearsago, the emergence of motor complications, such as levodopa-induced dyskinesias (LID), hasbeen a major clinical problem in advanced stages of the disease. Clinical and preclinical studieshave revealed a number of functional changes in the dopaminergic system that may be ofimportance for the emergence of LIDs. READ MORE

  2. 2. Dopaminergic 2-aminotetralins : synthesis, conformational analysis, and structure-activity relationships

    Author : Anette M. Johansson; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : .... READ MORE

  3. 3. Generation of Dopaminergic Neurons from Human Embryonic Stem Cells

    Author : Tandis Vazin; Joakim Lundeberg; Ernest Arenas; KTH; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Human; dopaminergic; embryonic stem cells; differentiation; stromal cells; PA6 cells; dopamine; neurons; Neuroscience; Neurovetenskap; Neurobiology; Neurobiologi; Molecular neurobiology; Molekylär neurobiologi;

    Abstract : Since the first successful derivation of human embryonic stem cells (hESC), rapid progress has been attained in the development of strategies in differentiation of these cells into various neural lineages, with the fundamental objective of using these cells for replacement and repair of damaged neuronal circuits in the central nervous system (CNS). Of particular interest are midbrain dopaminergic (mDA) neurons, which play a central role in regulation of voluntary movement. READ MORE

  4. 4. Functional and Transcriptional Studies of Human Dopaminergic Neurons

    Author : Marcella Birtele; Utvecklings- och regenerativ neurobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dopaminergic Neurons; Cell reprogramming; Cell therapy; Induced neurons; In vitro reprogramming; In vivo reprogramming;

    Abstract : Parkinson’s Disease (PD) is the most common movement disorder and second most common neurodegenerative disease. The principal hallmark of the pathology is represented by a loss of mesencephalic Dopaminergic neurons (mesDA) that reside in the Substantia Nigra pars compacta (SNpc). READ MORE

  5. 5. Intrinsic and extrinsic factors controlling the differentiation of human midbrain progenitor cells

    Author : Nicolaj Christophersen; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; neurotrophic factors; Parkinson s disease; microarray; dopaminergic; Embryonic stem cells; neural stem cells;

    Abstract : Parkinson's disease (PD) is a common neurodegenerative disorder characterized by motor deficits. Levodopa treatment provides marked symptomatic relief. However, within 5-10 years after the start of Levodopa treatment, most PD patients display a gradual loss of drug efficacy. READ MORE