Search for dissertations about: "dopaminergic"

Showing result 16 - 20 of 251 swedish dissertations containing the word dopaminergic.

2. 16. Wnt/beta-catenin signaling in midbrain dopaminergic neurons

   Author : Nina Rawal; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Dopamine; neuron; development; beta-catenin; Writ; Parkin; Parkinson s disease;

   Abstract : Parkinson's disease (PD) is caused by a progressive degeneration of the dopaminergic (DA) neurons of the substantia nigra. However, the mechanisms underlying the degeneration remain elusive and there is no cure for P1) at present. READ MORE

4. 17. The Wnt pathway in ventral midbrain dopaminergic differentiation

   Author : Diogo Ribeiro; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Parkinson’s disease (PD) is a debilitating neurodegenerative disease in which dopaminergic (DA) neurons in the substantia nigra are lost. Current treatments such as administration of levodopa (L-DOPA) are initially effective but the disease eventually progresses, highlighting the need for a treatment that restores and maintains the otherwise lost functions. READ MORE

5. 18. Towards cell replacement therapy in Parkinson’s disease. Proteoglycans and Nogo-A as modulators of axonal growth in midbrain dopaminergic neurons

   Author : Zuzanna Kurowska; Neural plasticitet och reparation; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LUHMES cells; substantia nigra pars compacta; microarray; heparan sulphate 3-O-sulfotransferase; neurocan; midbrain dopaminergic neurons; grafting; embryonic stem cells; proteoglycans; glycosaminoglycans; Nogo-A; cell replacement therapy; Parkinson’s disease;

   Abstract : Parkinson’s disease (PD) is currently the second most common neurodegenerative disorder (after Alzheimer’s disease). PD is diagnosed on its motor symptoms, which include akinesia, bradykinesia, rigidity, postural imbalance and resting tremor. It is well established that the motor symptoms develop due to lack of dopamine in the striatum. READ MORE

6. 19. Wnt signalling in the development of ventral midbrain dopaminergic neurons

   Author : Gonçalo de Sá e Sousa de Castelo-Branco; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Dopaminergic Neuron; Ventral Midbrain Development; Writs; Dickkopf; beta-catenin; GSK-3beta; Stem Cells; Neural Precursors;

   Abstract : Dopaminergic (DA) neurons in the ventral midbrain (VM) are one of the major cell types lost in Parkinson's disease (PD). Proof-of-principle exists for cell replacement therapies for PD, but wider application is halted by the unavailability of abundant sources of DA neurons. Stem cells might constitute one of these sources. READ MORE

7. 20. Nuclear receptor and Wnt function in developing dopaminergic neurons

   Author : Kyle Matthew Sousa; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The progressive degeneration of dopaminergic neurons in the substantia nigra is one of the major pathological events associated with Parkinson’s Disease. Dopaminergic (DA) cell replacement therapy has emerged in recent years as a possible approach towards treating Parkinsonism. READ MORE