Search for dissertations about: "dopaminergic"

Showing result 21 - 25 of 251 swedish dissertations containing the word dopaminergic.

  2. 21. Molecular and cellular characterization of midbrain dopaminergic neuron development

    Author : Daniel Gyllborg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Midbrain dopaminergic (mDA) development is a complex yet highly controlled mechanistic process that is conserved across species. The understanding of these molecular details can open windows to new avenues of therapeutic medicine. Parkinson’s disease (PD) is a debilitating neurological disorder that to date has no cure or established cause. READ MORE

  4. 22. The Complex Genetics behind Neurodegeneration and Susceptibility to Parkinson’s disease

    Author : Michael Jewett; Translationell Neurogenetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s Disease; α-synuclein; Dopaminergic Neurons; Susceptibility; GSTA4; Vra1; rAAV; 6-OHDA; En1; Linkage analysis; Congenic strains; Axonal swellings; QTL; Risk factors; Neuroprotection; Astrocytes;

    Abstract : Parkinson’s disease (PD) is the second most common neurodegenerative disorder and affects over 1% of people above the age of 65. This progressive and debilitating disease is usually thought of as a motor disease, with symptoms such as muscle rigidity, slowness of movement, and tremor at rest. READ MORE

  5. 23. Stem cell-based models to study cellular alterations in Parkinson’s Disease

    Author : Margarita Chumarina; Stamcellslaboratoriet för sjukdomsmodellering i det centrala nervsystemet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease; stem cells; IPSCs; dopaminergic neurons; oligodendrocytes; omics;

    Abstract : Parkinson’s Disease (PD) is the most prevalent neurodegenerative movement disorder. Despite investigative efforts into the pathogenesis of the disease, the aetiology and mechanism of PD remains unknown, with multiple factors and cellular pathways known to play a part. READ MORE

  6. 24. Exploring Patient-Specific Cell Replacement Therapy for Parkinson's Disease

    Author : Shelby Shrigley; Utvecklings- och regenerativ neurobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dopaminergic neurons; Parkinson s disease; cell replacement therapy; cellular reprogramming; alpha-synuclein;

    Abstract : Parkinson’s disease (PD) affects over six million people worldwide and is characterised by the progressive loss of dopaminergic (DA) neurons in the substantia nigra, accumulation of pathological alpha-synuclein (αSyn), and inflammation in the brain. This leads to motor impairments including rigidity, akinesia, bradykinesia, resting tremor, and postural instability. READ MORE

  7. 25. Generation of cells for cell-replacement therapy: Specification of neural precursors in vivo and in neural stem cell cultures

    Author : Josephine Hebsgaard; Neurobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurospheres; Dopaminergic neurons; Parkinson s disease; Neurogenin2;

    Abstract : Cell replacement therapy of neurodegenerative disorders aims to substitute the degenerating cells with new functional neurons. Clinical trails with patients suffering from Parkinson’s or Huntington’s disease have generated proof-of-principle results that neural precursors taken from the developing human brain can survive upon grafting to the diseased brain and provide long-lasting symptomatic relief. READ MORE