Search for dissertations about: "dorsal root ganglion"
Showing result 1 - 5 of 52 swedish dissertations containing the words dorsal root ganglion.
-
1. Effects of nucleus pulposus on nerve root circulation and function. Morphologic and functional studies in an experimental model using porcine spinal nerve roots
Abstract : Sciatica due to lumbar disc herniation has for many decades been viewed as a consequence of mechanical compression exerted on spinal nerve roots by the bulging disc tissues. Recent research has, however, indicated that extruded nucleus pulposus (NP) from the intervertebral disc might cause functional and endoneurial morphological changes in spinal nerve roots, without mechanical compression. READ MORE
-
2. Signaling Mechanisms in the Neuronal Networks of Pain and Itch
Abstract : Glutamate is the essential neurotransmitters in pain pathways. The discovery of the vesicular glutamate transporters (VGLUT1-3) has been a fundamental step on the way to describe glutamate-dependent pain pathways. We used the Cre-lox system to construct conditional knockouts with deficient Vglut2 transmission in specific neuronal populations. READ MORE
-
3. Sensory neuronal protection & improving regeneration after peripheral nerve injury
Abstract : Peripheral nerve trauma is a common cause of considerable functional morbidity, and healthcare expenditure. Particularly in the ~15% of injuries unsuitable for primary repair, standard clinical management results in inadequate sensory restitution in the majority of cases, despite the rigorous application of complex microsurgical techniques. READ MORE
-
4. Gene expression in the dorsal root ganglion and the role of PAI-1 and amphiregulin during regeneration
Abstract : This thesis is concerned with two aspects of peripheral nerve injury. First the early changes in the gene expression of the dorsal root ganglion (DRG) in response to sciatic nerve injury as revealed by micro-array analysis. Second an examination of the effect of PAI-1 and amphiregulin on survival and axonal outgrowth from DRG. READ MORE
-
5. Histochemical, biochemical and electrophysiological studies on dorsal root ganglion cultures : focusing on galanin, neuropeptide Y and glutamate
Abstract : Galanin (Gal) and neuropeptide Y (NPY) are two peptides, which are strongly up- regulated in a population of dorsal root ganglion (DRG) neurons after peripheral nerve injury (axotomy). Both peptides may be involved in the control of pain sensation, especially after nerve injury (neuropathic pain). READ MORE