Search for dissertations about: "dose escalation study"

Showing result 1 - 5 of 14 swedish dissertations containing the words dose escalation study.

2. 1. Model-Based Optimization of Clinical Trial Designs

   Author : Camille Vong; Mats O. Karlsson; Andrew C. Hooker; Lena E. Friberg; Marylore Chenel; Oliver Sander; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed-effects models; pharmacometrics; likelihood ratio test; NONMEM; power; sample size; study design; proof-of-concept; dose-finding; population optimal design; LOQ; BQL data; neutropenia; docetaxel; myelosuppression; thrombocytopenia; MTD; Bayesian methods; 3 3 algorithm; dose escalation study; Pharmaceutical Science; Farmaceutisk vetenskap;

   Abstract : General attrition rates in drug development pipeline have been recognized as a necessity to shift gears towards new methodologies that allow earlier and correct decisions, and the optimal use of all information accrued throughout the process. The quantitative science of pharmacometrics using pharmacokinetic-pharmacodynamic models was identified as one of the strategies core to this renaissance. READ MORE

4. 2. CT Urography : Efforts to Reduce the Radiation Dose

   Author : Pär Dahlman; Anders Magnusson; Anders Sundin; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Urinary tract malignancy; renal cell carcinoma; urography; x-ray computed tomography; radiation dosage; dose escalation; hematuria diagnosis; Diagnostic radiology; Diagnostisk radiologi; Radiologi; Radiology;

   Abstract : Computed tomography urography (CTU) is today the imaging method used to investigate patients with suspected urinary tract malignancy, replacing the old imaging method intravenous pyelography (IVP) about a decade ago. The downside of this shift was that the effective radiation dose to the examined patient was eight times higher for CTU compared to IVP. READ MORE

5. 3. Dose Escalation with High Dose Rate Brachytherapy or Protons in Curative Radiotherapy of Prostate Cancer

   Author : Lennart Åström; Lars Holmberg; Gunilla Enblad; Henrik Grönberg; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; radiotherapy; brachytherapy; high dose rate; protons; PSA bounce;

   Abstract : The aim of the thesis was to study the outcome and side effects after dose-escalated radiotherapy with high dose rate brachytherapy (HDR-BT) or proton beam therapy (PBT) boost in prostate cancer.The first cohorts of men in Sweden treated with either HDR-BT or PBT in combination with conventional photon beam therapy (2 Gray (Gy) fractions to 50 Gy) were analysed. READ MORE

6. 4. Optimisation of Chemotherapy Treatment in Advanced Colorectal Cancer

   Author : Åke Berglund; Ragnar Hultborn; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Colorectal cancer; chemotherapy; 5-fluorouracil; dose-effect relationship; ex vivo assay; thymidylate synthase; p53; CEA; TPS; VEGF; bFGF.; Onkologi; Oncology; Onkologi; Oncology; onkologi;

   Abstract : Colorectal cancer is one of the most common malignant diseases in Sweden – more than 5000 new cases are diagnosed each year. The overall five-year survival is about 60% and in cases of recurrence the prognosis is poor. READ MORE

7. 5. Radiotherapy in advanced head and neck cancer

   Author : Anna Embring; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Head and neck cancer (HNC) is a group of malignant tumours located in the mucosa of the upper aero-digestive tract. The location of the tumour, close to several critical organs, can often result in great suffering for the patient both due to the tumour itself but also the treatment can be associated with side effects impairing quality of life. READ MORE