Search for dissertations about: "dose finding"

Showing result 16 - 20 of 176 swedish dissertations containing the words dose finding.

  2. 16. Furosemide dosage input : consequences for diuretic effect, tolerance and efficiency

    Author : Monique Wakelkamp; Karolinska Institutet; Karolinska Institutet; []
    Keywords : furosemide; drug input rate; pharmacokinetics; pharmacodynamics; tolerance; efficiency; probenecid;

    Abstract : The development of new dosage forms raises the question of how the pharmacokinetic pharmacodynamic (PK-PD) profile of a drug is influenced by the drug input rate. Furosemide was used as a model drug to study the relationship between drug input rate and effect. READ MORE

  4. 17. Interlaced proton grid therapy: development of an innovative radiation treatment technique

    Author : Thomas Henry; Irena Gudowska; Tony Lomax; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proton therapy; grid therapy; spatially fractionated therapy; interlacing; Medical Radiation Physics; medicinsk strålningsfysik;

    Abstract : Spatially fractionated radiotherapy, also known as grid therapy (GRID), has been used for more than a century to try to treat several kinds of lesions. Yet, the grid technique remains a relatively unknown and uncommon treatment modality nowadays. READ MORE

  5. 18. Exploratory clinical development of ropivacaine, a local anaesthetic, in ulcerative colitis

    Author : Eva Arlander; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Drug development; ulcerative colitis; ropivacaine; rectal administration; pharmacokinetics; metabolism.;

    Abstract : The aims of this thesis were to explore the clinical pharmacology of ropivacaine gel as a potential new rectal therapy for ulcerative colitis (UC). The studies included pharmacokinetics, tolerability, preliminary efficacy in patients, formulation factors and drug-drug interactions. READ MORE

  6. 19. Neuroendocrine tumors of the digestive system : Modulation of apoptosis and factors associated with growth regulation during biotherapies

    Author : S. A. Hassan Imam; Uppsala universitet; []
    Keywords : Medical sciences; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Abstract : Neuroendocrine tumors of the gut have the potential to create life-threatening syndromes which become difficult to treat. Tumor mass reduction, by medical therapy, is one of the choices of treatments. READ MORE

  7. 20. UV-induced DNA damage in humans

    Author : Vladimir J Bykov; Karolinska Institutet; Karolinska Institutet; []
    Keywords : 32P-HPLC; photoproducts; DNA repair; solar simulated radiation; erythema; sunscreens; humans;

    Abstract : Ultraviolet radiation is considered to be the most harmful part of solar energy affecting man. The depletion of the ozone layer around the Earth increases the total exposure to UV-light. The incidence of skin cancer in man has been shown to be associated with exposure to solar radiation, especially to UV-light. READ MORE