Search for dissertations about: "dose quantification"

Showing result 1 - 5 of 68 swedish dissertations containing the words dose quantification.

2. 1. Quantification Methods for Clinical Studies in Nuclear Medicine - Applications in AMS, PET/CT and SPECT/CT

   Author : Marie Sydoff; Malmö Medicinsk strålningsfysik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Nuclear Medicine; AMS; PET CT; SPECT CT; dosimetry; internal dosimetry; quantification; activity quantification; volume delineation; radiation; biokinetics; pharmacokinetics; biodistribution;

   Abstract : An essential part of the development of new radiopharmaceuticals for use in diagnostic nuclear medicine is the determination of its biokinetic properties. The uptake and turn-over of the radiopharmaceutical in the source organs is of great interest since this could determine whether the radiopharmaceutical would be suitable for clinical use or not. READ MORE

4. 2. Quantification of Radiation Induced DNA Damage Response in Normal Skin Exposed in Clinical Settings

   Author : Martin Simonsson; Ingela Turesson; Gunilla Enblad; Dag Rune Olsen; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA damage response; low-dose hypersensitivity; dose response; normal tissue; epidermis; dermis; keratinocyte; fractionated radiotherapy; DNA double strand break; DSB; foci; gamma-H2AX; 53BP1; p21; checkpoint; apoptosis; mitosis; micro-RNA; miR-34a; Oncology; Onkologi; Oncology; Onkologi;

   Abstract : The structure, function and accessibility of epidermal skin provide aunique opportunity to study the DNA damage response (DDR) of a normaltissue. The in vivo response can be examined in detail, at a molecularlevel, and further associated to the structural changes, observed at atissue level. READ MORE

5. 3. Image Processing for Quantitative Scintillation-Camera Imaging. Application to Radionuclide Therapy

   Author : Katarina Sjögreen Gleisner; Lund Medicinsk strålningsfysik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tomografi; radiologi; Klinisk fysiologi; medical instrumentation; tomography; radiology; 131-I; Clinical physics; SPECT; conjugate-view; volume quantification; activity quantification; image registration; image segmentation; medicinsk instrumentering; Nuclear medicine; radiobiology; Nukleärmedicin; radiobiologi; Radiopharmaceutical technology; Radiofarmaceutisk teknik;

   Abstract : Individual-based determinations of the absorbed dose in radionuclide therapy largely rely on absolute measurement of the activity distribution and its redistribution over time. Scintillation-camera imaging is the most commonly employed measuring technique, applied in planar or SPECT mode, sometimes in combination with structural images from CT. READ MORE

6. 4. Biomarkers of internal exposure/dose : Methods to quantify adducts to protein and DNA by LC/MS studied with benzo[a]pyrene and isocyanates

   Author : Emelie Westberg; Margareta Törnqvist; Kimmo Peltonen; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; biomarker; PAH; serum albumin; adduct; DNA; isocyanate; miljökemi; Environmental Chemistry;

   Abstract : This thesis focuses on methods for quantification by liquid chromatography/mass spectrometry (LC/MS) of specific biomarkers for internal dose of chemicals which induce toxicity through their electrophilic reactivity. In vivo such compounds are short-lived, and could feasibly be measured as their reaction products (adducts) with biomacromolecules. READ MORE

7. 5. New single particle methods for detection and characterization of nanoparticles in environmental samples

   Author : Jani Tuoriniemi; Göteborgs universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Nanoparticles; Detection; Quantification; Metrology; Trace particle;

   Abstract : Nanoparticles (NP) are being used in rapidly increasing quantities which has resulted in concerns about possible harmful effects for health and environment. NP are already undergoing similar risk assessment programs as conventional chemicals, and due to their enhanced surface reactivities it has been proposed that the use of NP should be regulated by specific legislation based on particle size. READ MORE