Search for dissertations about: "dose response"
Showing result 6 - 10 of 882 swedish dissertations containing the words dose response.
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6. In vivo dose, dose-response and cancer risk assessment
Abstract : .... READ MORE
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7. Cellular effects of ionizing radiation : Relevant for understanding cancer risk after medical and environmental radiation exposures
Abstract : Radiation-induced cancers are stochastic and delayed effects of exposure to ionizing radiation. The dose-response relationship for radiation-induced cancers at both low dose/low dose rates and high doses (doses encountered during radiotherapy) remains unclear. READ MORE
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8. Optimal (Adaptive) Design and Estimation Performance in Pharmacometric Modelling
Abstract : The pharmaceutical industry now recognises the importance of the newly defined discipline of pharmacometrics. Pharmacometrics uses mathematical models to describe and then predict the performance of new drugs in clinical development. READ MORE
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9. Pharmacometric Investigations of Prediction Precision and Advances of Models for Composite Scale Data
Abstract : Clinical trials are needed to evaluate new treatments. In late-stage clinical trials, failures are mostly due to lack of efficacy. Fit-for-purpose analysis methods will likely increase the success rates and advance drug development by providing higher precision to support decisions such as go/no-go, dose selection, or sample size. READ MORE
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10. Estimation and optimal designs for multi-response Emax models
Abstract : This thesis concerns optimal designs and estimation approaches for a class of nonlinear dose response models, namely multi-response Emax models. These models describe the relationship between the dose of a drug and two or more efficacy and/or safety variables. READ MORE