Search for dissertations about: "dose-response parameters"
Showing result 1 - 5 of 37 swedish dissertations containing the words dose-response parameters.
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1. Pharmacometric Investigations of Prediction Precision and Advances of Models for Composite Scale Data
Abstract : Clinical trials are needed to evaluate new treatments. In late-stage clinical trials, failures are mostly due to lack of efficacy. Fit-for-purpose analysis methods will likely increase the success rates and advance drug development by providing higher precision to support decisions such as go/no-go, dose selection, or sample size. READ MORE
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2. Optimal (Adaptive) Design and Estimation Performance in Pharmacometric Modelling
Abstract : The pharmaceutical industry now recognises the importance of the newly defined discipline of pharmacometrics. Pharmacometrics uses mathematical models to describe and then predict the performance of new drugs in clinical development. READ MORE
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3. Quantification of Radiation Induced DNA Damage Response in Normal Skin Exposed in Clinical Settings
Abstract : The structure, function and accessibility of epidermal skin provide aunique opportunity to study the DNA damage response (DDR) of a normaltissue. The in vivo response can be examined in detail, at a molecularlevel, and further associated to the structural changes, observed at atissue level. READ MORE
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4. Dose-response modeling : evaluation, application, and development of procedures for benchmark dose analysis in health risk assessment of chemical substances
Abstract : In this thesis, dose-response modeling and procedures for benchmark dose (BMD) analysis in health risk assessment of chemical substances have been investigated. The BMD method has been proposed as an alternative to the NOAEL (no-observedadverse- effect-level) approach in health risk assessment of non-genotoxic agents. READ MORE
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5. Techniques for the increased utilization of dose response variability in proton therapy
Abstract : Particle therapy is a form of radiation therapy in which protons and heavier ions are used, as opposed to photons in conventional radiation therapy. The biological effectiveness of particles compared to photons is often quantified as relative biological effectiveness (RBE). READ MORE