Search for dissertations about: "dried blood spots"

Showing result 1 - 5 of 17 swedish dissertations containing the words dried blood spots.

  1. 1. Dried blood sampling and digital readout to advance molecular diagnostics

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Johan Björkesten; Uppsala universitet.; Uppsala universitet.; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; molecular diagnostics; dried blood sample; DBS; digital readout; digital enumeration; DNA detection methods; proximity extension assay; protein stability; genotyping; rare mutations; cell free DNA; multiplex protein measurement.; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : A drastically increased capacity to measure large sets of molecular features in numerous patient samples in great detail will be required to fulfill the vision of precision medicine and wellness, which may characterize molecular diagnostics in the 21st century. Also sampling procedures need a renaissance to permit continuous sampling at population levels at reasonable cost. READ MORE

  2. 2. Capillary driven devices for patient-centric diagnostics

    University dissertation from Stockholm : Kungliga Tekniska högskolan

    Author : Gabriel Lenk; KTH.; [2018]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Capillary driven; Microfluidic; Dissolvable valves; PVA; Volume metering; Dried Blood Spots; DBS; Dried Plasma Spots; DPS; Medicinsk teknologi; Medical Technology;

    Abstract : Lateral flow assays is an example of a successful microfluidic platform relying on passive fluid transport, making them suitable for patient-centric and point-of-care applications. Flow control and valving in capillary driven devices typically rely on design-imprinted functions and operations which can be a limiting factor. READ MORE

  3. 3. Development of Analytical Methods for the Determination of Antimalarials in Biological Fluids

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Daniel Blessborn; Uppsala universitet.; Högskolan Dalarna.; [2009]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES Chemistry; NATURVETENSKAP Kemi; Malaria; Chloroquine; Quinine; Sulfadoxine; Pyrimethamine; Mefloquine; Lumefantrine; Amodiaquine; Pyronaridine; Proguanil; Atovaquone; Sampling paper; Dried blood spots; Capillary blood; Antimalarial drugs; Solid-phase extraction; Liquid chromatography.;

    Abstract : The aim of this thesis was to develop analytical methods for measuring antimalarial drugs in biological fluids. Solid phase extraction (SPE) was used for the enrichment and purification of the drugs. READ MORE

  4. 4. Development and Validation of Bioanalytical Methods Application to Melatonin and Selected Anti-Infective Drugs

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Susanne Römsing; Uppsala universitet.; Högskolan Dalarna.; [2010]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES Chemistry; NATURVETENSKAP Kemi; Analytical Chemistry; Analytisk kemi; african trypanosomiasis; melatonin; malaria; antiretroviral drugs; lumefantrine; tafenoquine; lamivudine; nevirapine; zidovudine; sampling paper; dried blood spots; capillary blood; antimalarial drugs; solid-phase extraction; liquid chromatography;

    Abstract : This thesis describes bioanalytical methods for measuring melatonin and some anti-infective drugs in biological fluids. Solid-phase extraction (SPE) or protein precipitation was used for enrichment and purification of the analytes and Liquid Chromatography (LC) was used to analyze the samples. READ MORE

  5. 5. Development of Field-adapted Analytical Methods for the Determination of New Antimalarial Drugs in Biological Fluids

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Niklas Lindegårdh; Uppsala universitet.; Högskolan Dalarna.; [2003]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES Chemistry Analytical chemistry; NATURVETENSKAP Kemi Analytisk kemi; Analytical Chemistry; analytisk kemi; Analytical chemistry; LC; liquid chromatography; biological samples; SPE; solid phase extraction; validation; antimalarial drugs; amodiaquine; piperaquine; atovaquone; dried blood spots; Analytisk kemi;

    Abstract : This thesis deals with the development of analytical methods for the determination of new antimalarial drugs in biological fluids. The goal was to develop methods that facilitate clinical studies performed in the field, such as capillary blood sampling onto sampling paper. READ MORE