Search for dissertations about: "drug degradation"
Showing result 1 - 5 of 140 swedish dissertations containing the words drug degradation.
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1. Drug Eluting Hydrogels : Design, Synthesis and Evaluation
Abstract : Hydrogels have successfully proved themselves useful for drug delivery applications and several delivery routes have been developed over the years. The particular interest in this work was to design, synthesise and evaluate in situ forming drug eluting hydrogels, which have the potential to ameliorate the healing of cardiovascular diseases. READ MORE
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2. Structural studies of drug targets and a drug metabolizing enzyme
Abstract : The work presented in this thesis describes how structural information about a protein can be acquired, and how it can be used to answer scientific questions about proteins’ function, their dynamic behaviour and their interactions with other proteins or ligands.The catalytic function of the pyrimidine-degrading, drug metabolizing enzyme β-ureidopropionase (βUP) is dependent on the shift between oligomeric states. READ MORE
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3. Development and Evaluation of Lipodisks Intended for Use as Biomimetic Membranes and Drug Carriers
Abstract : Polyethylene glycol-stabilized lipodisks have emerged as a novel type of lipid-based nanoparticles with high potential as both drug carriers and biomimetic membranes. In this thesis we assess both of these applications, and show how the properties of the lipodisks can be further developed and optimized. READ MORE
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4. In vitro and in silico Predictions of Hepatic Transporter-Mediated Drug Clearance and Drug-Drug Interactions in vivo
Abstract : The liver is the major detoxifying organ, clearing the blood from drugs and other xenobiotics. The extent of hepatic clearance (CL) determines drug exposure and hence, the efficacy and toxicity associated with exposure. Drug-drug interactions (DDIs) that alter the hepatic CL may cause more or less severe outcomes, such as adverse drug reactions. READ MORE
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5. Bacteria-responsive materials for drug delivery
Abstract : The number of diabetics, obese individuals and other patients carrying other lifestyle diseasesis increasing worldwide. At the same time the population is ageing. These patients all sufferfrom poor blood circulation, which often gives rise to non-healing, or chronic, wounds. Thus,the number of chronic wounds is also increasing at a fast pace. READ MORE
