Search for dissertations about: "drug delivery"

Showing result 1 - 5 of 289 swedish dissertations containing the words drug delivery.

  1. 1. Pulmonary Drug Absorption In vitro and in vivo investigations of drug absorption across the lung barrier and its relation to drug physicochemical properties

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Ann Tronde; Gerrit Borchard; [2002]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; lung; pulmonary; drug delivery; inhalation; drug transport; pharmacokinetics; absorption; bioavailability; drug metabolism; preclinical; rat; in vivo; isolated and perfused lung; Caco-2; nebulization catheter; aerosol; physicochemical; peptide; efflux; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; biofarmaci;

    Abstract : Although, pulmonary drug delivery is a well established means for targeting of drugs to the lungs for the treatment of respiratory diseases as well as for the systemic delivery of volatile anesthetic agents, drug absorption kinetics in the lung have not been subjected to extensive research. The main objective of this thesis was to investigate drug absorption characteristics of the lung barrier, using the isolated and perfused rat lung model and in vivo pharmacokinetic studies in rats. READ MORE

  2. 2. Nasal Drug Delivery In Vitro Studies on Factors Influencing Permeability and Implications on Absorption

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Cecilia Wadell; Frans Merkus; [2002]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; galenisk farmaci; Pharmaceutics;

    Abstract : Nasal delivery is a feasible alternative to oral or parenteral administration for some drugs because of the high permeability of the nasal epithelium, rapid drug absorption across this membrane and avoidance of hepatic first-pass metabolism. The main objective of this thesis was to investigate factors influencing the permeability of the nasal mucosa to various compounds and to evaluate implications for drug absorption via the nasal route. READ MORE

  3. 3. Ocular drug delivery : studies on corneal permeability and an evaluation of prostaglandin F2a pro-drugs and sodium hyaluronate

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Ola Camber; [1987]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : .... READ MORE

  4. 4. Drug Delivery to the Brain by Liposomes Understanding Factors Governing Delivery Outcomes In Vivo

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Yang Hu; Margareta Hammarlund-Udenaes; Teresa Dalla Costa; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nanocarrier; liposome; blood-brain barrier; brain delivery; formulation; methotrexate; diphenhydramine; microdialysis; pharmacokinetics; model-based approach; Farmaceutisk vetenskap; Pharmaceutical Science; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

    Abstract : The blood-brain barrier (BBB) is the primary obstacle for efficient drug delivery to the central nervous system (CNS). One promising strategy to enhance brain delivery is to utilize nanocarriers (NC), e.g., liposomes, encapsulating CNS drugs. READ MORE

  5. 5. Rational modifications of cell-penetrating peptides for drug delivery Applications in tumor targeting and oligonucleotide delivery

    University dissertation from Stockholm : Institutionen för neurokemi

    Author : Maarja Mäe; Ülo Langel; Edvard Smith; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell-penetrating peptide; oligonucleotide; drug delivery; tumor targeting; MEDICINE Chemistry Neurochemistry; MEDICIN Kemi Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Abstract : High molecular weight biomolecules are becoming important in the development of new therapeutics. However, their size and nature creates a major limitation for their application – poor penetration through biological membranes. READ MORE