Search for dissertations about: "drug development"

Showing result 1 - 5 of 943 swedish dissertations containing the words drug development.

  2. 1. Drug Analysis : Bioanalytical Method Development and Validation

    University dissertation from Uppsala : Uppsala: Uppsala universitet, Fakultetsövergripande enheter, Acta Universitatis Upsaliensis

    Author : Mikaela Malm; [2008]
    Keywords : African trypanosomiasis; calibration model; chiral chromatography; dried blood spots; eflornithine; evaporative light-scattering detection; HIV AIDS; lamivudine; liquid chromatography; malaria; nevirapine; piperaquine; pneumonia; solid-phase extraction; sulfadoxine; sulfamethoxazole; validation; zidovudine;

    Abstract : This thesis describes bioanalytical methods for drug determination in biological matrixes, with drugs in focus used against diseases largely affecting low-income countries. Solid-phase extraction is used for sample cleanup, and processed samples are analyzed by liquid chromatography. READ MORE

  4. 2. Drug Analysis Bioanalytical Method Development and Validation

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Mikaela Malm; Yngve Bergqvist; Anders Colmsjö; [2008]
    Keywords : Analytical chemistry; African trypanosomiasis; calibration model; chiral chromatography; dried blood spots; eflornithine; evaporative light-scattering detection; HIV AIDS; lamivudine; liquid chromatography; malaria; nevirapine; piperaquine; pneumonia; solid-phase extraction; sulfadoxine; sulfamethoxazole; validation; zidovudine; Analytisk kemi;

    Abstract : This thesis describes bioanalytical methods for drug determination in biological matrixes, with drugs in focus used against diseases largely affecting low-income countries.Solid-phase extraction is used for sample cleanup, and processed samples are analyzed by liquid chromatography. READ MORE

  5. 3. Circumventing drug resistance : Studies exploring the expediency of a total cell kill chemoresistance assay

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Bertil Jonsson; [1998]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical sciences; drug resistance; drug resistance assay; clinical correlations; cancer; human; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Abstract : Cellular resistance to anti-cancer drugs is considered to be the major cause of treatment failure in clinical practice. The present studies have therefore focused on ways to circumvent resistance as evaluated by an in vitro chemoresistance assay. READ MORE

  6. 4. Biosensor Studies of Ligand Interactions with Structurally Flexible Enzymes Applications for Antiviral Drug Development

    University dissertation from Uppsala : Institutionen för naturvetenskaplig biokemi

    Author : Matthis Geitmann; U. Helena Danielson; Marc H. V. van Regenmortel; [2005]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; SPR biosensor; HIV-1 reverse transcriptase; HCMV protease; interaction kinetics; drug discovery; non-nucleoside inhibitor; resistance; Biokemi; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi;

    Abstract : The use of a surface plasmon biosensor fills a missing link in kinetic studies of enzymes, since it measures directly the interaction between biomolecules and allows determination of parameters that are determined only indirectly in activity assays. The present thesis deals with kinetic and dynamic aspects of ligand binding to two viral enzymes: the human cytomegalovirus (HCMV) protease and the human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT). READ MORE

  7. 5. Modeling the Interaction Space of Biological Macromolecules: A Proteochemometric Approach Applications for Drug Discovery and Development

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Aleksejs Kontijevskis; Jarl Wikberg; Jan Komorowski; Robert Glen; [2008]
    Keywords : Bioinformatics; proteochemometrics; bioinformatics; chemoinformatics; chemical space; QSAR; retroviral proteases; HIV-1; drug resistance; pharmacogenomics; cytochrome P450; GPCRs; melanocortin receptors; interactome; machine-learning; rough sets; Bioinformatik;

    Abstract : Molecular interactions lie at the heart of myriad biological processes. Knowledge of molecular recognition processes and the ability to model and predict interactions of any biological molecule to any chemical compound are the key for better understanding of cell functions and discovery of more efficacious medicines. READ MORE