Search for dissertations about: "drug development"

Showing result 6 - 10 of 1151 swedish dissertations containing the words drug development.

2. 6. Modeling the Interaction Space of Biological Macromolecules: A Proteochemometric Approach : Applications for Drug Discovery and Development

   Author : Aleksejs Kontijevskis; Jarl Wikberg; Jan Komorowski; Robert Glen; Uppsala universitet; []
   Keywords : Bioinformatics; proteochemometrics; bioinformatics; chemoinformatics; chemical space; QSAR; retroviral proteases; HIV-1; drug resistance; pharmacogenomics; cytochrome P450; GPCRs; melanocortin receptors; interactome; machine-learning; rough sets; Bioinformatik;

   Abstract : Molecular interactions lie at the heart of myriad biological processes. Knowledge of molecular recognition processes and the ability to model and predict interactions of any biological molecule to any chemical compound are the key for better understanding of cell functions and discovery of more efficacious medicines. READ MORE

4. 7. Safety and Efficacy Modelling in Anti-Diabetic Drug Development

   Author : Bengt Hamrén; Mats O Karlsson; Eric Snoeck; Uppsala universitet; []
   Keywords : Pharmaceutical biosciences; pharmacokinetic; pharmacodynamic; mechanism-based; modelling; type 2 diabetes mellitus; tesaglitazar; PPAR; drug development; NONMEM; Farmaceutisk biovetenskap;

   Abstract : A central aim in drug development is to ensure that the new drug is efficacious and safe in the intended patient population. Mathematical models describing the pharmacokinetic-pharmacodynamic (PK-PD) properties of a drug are valuable to increase the knowledge about drug effects and disease and can be used to inform decisions. READ MORE

5. 8. Exploring Cancer Drugs In Vitro and In Vivo : With Special Reference to Chemosensitivity Testing and Early Clinical Development

   Author : Anne von Heideman; Peter Nygren; Bengt Tholander; Rolf Larsson; Seija Grénman; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytotoxic drug; in vitro assay; drug development; phase I clinical trial; Oncology; Onkologi; Oncology; Onkologi;

   Abstract : The aims of this thesis were to investigate the utility of in vitro drug sensitivity testing to optimize the use of cancer chemotherapy and to assess the properties of a new cancer drug in a phase I clinical trial. Tumour cells from patients were analysed with the short-term Fluorometric Microculture Cytotoxicity Assay (FMCA). READ MORE

6. 9. Fragment-based drug discovery : Novel methods and strategies for identifying and evolving fragment leads

   Author : Edward A. FitzGerald; Helena Danielson; Hanna-Kirsti Schrøder Leiros; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Drug Discovery; Biophysics; Fragment-based drug discovery; Epigenetics; Biosensors; Surface Plasmon Resonance; Interaction Analysis; Second-Harmonics; Biokemi; Biochemistry;

   Abstract : The need for new drugs became ever more apparent in the year 2020 when the world was faced with a viral pandemic. How drugs are discovered and their relevance to society became part of daily discussions in workplaces and homes throughout the world. Consequently, efficient strategies for preclinical drug discovery are clearly needed. READ MORE

7. 10. Practical Optimal Experimental Design in Drug Development and Drug Treatment using Nonlinear Mixed Effects Models

   Author : Joakim Nyberg; Andrew C. Hooker; Mats O. Karlsson; Sergei Leonov; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; optimal design; nonlinear mixed effects models; robust design; optimizing drug development; population models; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

   Abstract : The cost of releasing a new drug on the market has increased rapidly in the last decade. The reasons for this increase vary with the drug, but the need to make correct decisions earlier in the drug development process and to maximize the information gained throughout the process is evident. READ MORE