Search for dissertations about: "drug disposition"

Showing result 16 - 20 of 41 swedish dissertations containing the words drug disposition.

  2. 16. Studies on Variability in Olanzapine Disposition

    Author : Elisabeth Skogh; Staffan Hägg; Marja Liisa Dahl; Markus Heilig; Lena Flyckt; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Schizophrenia and schizoaffective disorders are chronic conditions with a significant impact on many functions. Positive, negative, cognitive and motor symptoms appear in different degrees and constellations. Antipsychotics are of fundamental importance to reduce symptoms. READ MORE

  4. 17. Studies of drug disposition in hemodialysis patients : impact of genetics, inflammation and vitamin D

    Author : Hadi Molanaei; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Chronic kidney disease (CKD) patients are at a high risk for drug adverse effects due to accumulation of drugs, which normally are excreted via the kidneys. It is believed that drugs that are metabolized by the liver are safe to prescribe in normal doses to end-stage renal disease (ESRD) patients. READ MORE

  5. 18. Studies on the enantioselective disposition of amlodipine : A challenge in bioanalysis

    Author : Martin Josefsson; Martin Ahnoff; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : To study the disposition of the enantiomers of the calcium channel blocker amlodipine in human plasma, an enantioselective high performance liquid chromatographic (HPLC) assay was developed. Several HPLC techniques such as chiral ion-pair forming, chiral derivatisation and direct separation on chiral columns were evaluated. READ MORE

  6. 19. CYP2C19 polymorphisms in drug metabolism and response

    Author : Ming Chang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Individuals vary widely in their response to drug treatment. After receiving doses of a drug that are recommended based on a population average, some patients could have an insufficient response, whereas others may experience adverse effects. READ MORE

  7. 20. The Hepatobiliary Transport of Rosuvastatin In Vivo

    Author : Ebba Bergman; Hans Lennernäs; Ulf Bondesson; Jack Cook; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rosuvastatin; Biliary excretion; Transport inhibition; Pharmacokinetics; Drug-drug interactions; Hepatobiliary transport; Organic anion transporting polypeptide; OATP; Statins; Gemfibrozil; Cyclosporine; Imatinib; Rifampicin; Canalicular transport; Sinusoidal transport; Hepatic uptake; Hepatic extraction; Biopharmacy; Biofarmaci; Biopharmaceutics; biofarmaci;

    Abstract : In vivo studies of hepatobiliary disposition are challenging. The hepatobiliary system is complex, as its physiological localization, complex cellular structure with numerous transporters and enzymes, and the interindividual variability in protein expression and biliary flow will all affect the in vivo disposition of a drug under investigation. READ MORE