Search for dissertations about: "drug distribution"

Showing result 16 - 20 of 216 swedish dissertations containing the words drug distribution.

  2. 16. Stereoselective Transport of Drugs Across the Blood-Brain Barrier (BBB) In Vivo and In Vitro : Pharmacokinetic and Pharmacodynamic Studies of the (S)- and (R)-Enantiomers of Different 5-HT1A Receptor Agonists and Antagonists

    Author : Hongmei Yan; Lennart Paalzow; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; pindolol; propranolol; 2- di-n-propylamino tetralin; racemate; enantiomer; drug distribution; brain; rat; blood-brain barrier; Neurovetenskap; Neurology; Neurologi; Psychiatry; psykiatri;

    Abstract : Delivery of drugs to the brain requires passage across the blood-brain barrier (BBB). Both for drugs already on the market and for new drugs under development, it is important to know to what extent a drug enters the CNS. Many drugs used clinically are racemic mixtures, i.e. READ MORE

  4. 17. Nanosized Bilayer Disks as Model Membranes for Interaction Studies

    Author : Anna Lundquist; Katarina Edwards; Marja-Liisa Riekkola; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Disk; disc; lipid bilayer; PEG-lipid; model membrane; interaction; partitioning; drug; liposome; cryo-TEM; neutron scattering; capillary electrophoresis; immobilization; biosensor; membrane protein; melittin; Chemistry; Kemi;

    Abstract : PEG-lipid stabilized bilayer disks have been found in lipid mixtures containing polyethylene glycol (PEG)-lipids where the combination of a high bending rigidity and low PEG-lipid/lipid miscibility favours disk formation. The disks are planar and circular in shape and their long-term stability is excellent. READ MORE

  5. 18. Pharmacokinetic dosing of factor VIII and factor IX in prophylactic treatment of haemophilia

    Author : Maj Carlsson; Malmö Klinisk koagulationsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Haematology; Prophylaxis; Pharmacokinetics; Pharmaceutical service; Haemophilia B; Haemophilia A; Factor IX; Factor VIII; Drug distribution; Cost-effectiveness; Dosage; extracellular fluids; Hematologi; extracellulära vätskor;

    Abstract : The aim of the thesis was to increase cost-effectiveness in prophylactic treatment of haemophilia. Prophylaxis is effective to prevent bleedings and arthropathy, but the high cost limits its use. First, a new distribution system for clotting factor concentrates was implemented in Sweden to improve availability and reduce risks and costs. READ MORE

  6. 19. Diffusion Controlled Drug Release from Slurry Formed, Porous, Organic and Clay-derived Pellets

    Author : Erik Jämstorp Berg; Maria Strømme; Håkan Engqvist; Susanne Bredenberg; Pentti Tengvall; Nanoteknologi och funktionella material Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diffusion; Drug delivery; Antithrombotic drugs; Highly potent opioids; Modeling; Clays; Polymers; Pellets; Beads; Materialvetenskap; Materials Science;

    Abstract : Coronary artery disease and chronic pain are serious health issues that cause severe discomfort and suffering in society today. Antithrombotic agents and highly potent analgesics play a critical role in improving the recovery process for patients being treated for these diseases. READ MORE

  7. 20. Novel Pharmacometric Methods for Informed Tuberculosis Drug Development

    Author : Oskar Clewe; Ulrika S.H. Simonsson; Mats O. Karlsson; Piet van der Graaf; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; pharmacodynamics; PKPD; pharmacometric; nonlinear mixed-effects models; multistate tuberculosis pharmacometric model; general pharmacodynamic interaction model; general pulmonary distribution model; tuberculosis; rifampicin; isoniazid; ethambutol; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : With approximately nine million new cases and the attributable cause of death of an estimated two millions people every year there is an urgent need for new and effective drugs and treatment regimens targeting tuberculosis. The tuberculosis drug development pathway is however not ideal, containing non-predictive model systems and unanswered questions that may increase the risk of failure during late-phase drug development. READ MORE