Search for dissertations about: "drug distribution"
Showing result 6 - 10 of 215 swedish dissertations containing the words drug distribution.
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6. Proteomics informed investigation of human hepatocytes and liver tissue
Abstract : A successful drug needs to display beneficial absorption, distribution, metabolism, excretion and toxicity (ADME-Tox) profile. It is therefore important to investigate these properties during the drug discovery process. READ MORE
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7. In vitro and in silico prediction of drug-drug interactions with transport proteins
Abstract : Drug transport across cells and cell membranes in the human body is crucial for the pharmacological effect of drugs. Active transport governed by transport proteins plays an important role in this process. A vast number of transport proteins with a wide tissue distribution have been identified during the last 15 years. READ MORE
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8. Biopharmaceutical Evaluation of Intra-arterial Drug-Delivery Systems for Liver Cancer : Investigations in healthy pigs and liver cancer patients
Abstract : There are currently two types of intra-arterial drug-delivery system (DDS) in clinical use in the palliative treatment of primary liver cancer. The chemotherapeutic drug doxorubicin (DOX) can be formulated into a drug-in-lipiodol emulsion (LIPDOX) or a microparticulate drug-eluting bead system (DEBDOX). READ MORE
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9. Drug policing of youth : examining pre- and post-stop conditions and outcomes
Abstract : Given the strong focus on minor drug offenses in Swedish drug control policy and the risk of disparate drug enforcement that may follow from such policies, this thesis explores drug enforcement and the use of coercive measures (enforced drug tests and body searches) towards youths aged 15-20 years. The first study focuses on the circumstances of the detection of minor drug offenses, the grounds for suspicion and use of coercive measures. READ MORE
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10. Mesoporous Implants for Localized Controlled Drug Delivery
Abstract : The use of bone-anchored implants is today a routine treatment for patients with normal regenerative capacity. However, there is an ongoing development within implant research to improve the osseointegration of implants. READ MORE