Search for dissertations about: "drug efflux"
Showing result 21 - 25 of 72 swedish dissertations containing the words drug efflux.
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21. Plasmodium falciparum drug transporter genes in emerging malaria multidrug resistance
Abstract : Malaria is caused by an intracellular protozoan parasite of the genus Plasmodium. The use of chemotherapy, the foremost tool available for the control of the disease, has been challenged in the last decades by the development and spread of drug resistance among malaria parasites. READ MORE
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22. Drug resistance in acute myeloid leukemia : clinical and experimental studies
Abstract : The long-term result of chemotherapy in acute myeloid leukemia (AML) is poor, even though a majority of AML patients initially respond to chemotherapy and achieve complete remission (CR). Initially resistant disease as well as relapse is a result of resistance to chemotherapy drug resistance. READ MORE
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23. Chloride transport and inflammation in cystic fibrosis airways
Abstract : Cystic fibrosis (CF) is one of the most common lethal, autosomal recessive inherited diseases among Caucasians. It is caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR), a chloride channel activated by cyclic AMP. READ MORE
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24. Copper-transporting proteins and their interactions with platinum-based anticancer substances
Abstract : Cisplatin (CisPt) is an important drug that is used against various cancers, including testicular, ovarian, lung, head, and neck cancer. However, its effects are limited by cellular resistance. READ MORE
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25. Modelling Approaches to Molecular Systems Biology
Abstract : Implementation and analysis of mathematical models can serve as a powerful tool in understanding how intracellular processes in bacteria affect the bacterial phenotype. In this thesis I have implemented and analysed models of a number of different parts of the bacterium E. coli in order to understand these types of connections. READ MORE