Search for dissertations about: "drug monitoring"

Showing result 1 - 5 of 167 swedish dissertations containing the words drug monitoring.

  1. 1. Therapeutic Drug Monitoring in Psychiatry Some aspects of utility in clinical practice and research

    University dissertation from Linköping : Linköping University Electronic Press

    Author : Maria Dolores Chermá Yeste; Linköpings universitet.; Linköpings universitet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TDM; psychoactive drug; pharmacokinetics; pharmacogenetics; naturalistic; elderly; child; MEDICINE Physiology and pharmacology Pharmacological research Clinical pharmacology; MEDICIN Fysiologi och farmakologi Farmakologisk forskning Klinisk farmakologi;

    Abstract : Background and objectives: Several new psychoactive drugs for the treatment of psychiatric disorders have been introduced onto the market since the late 1980s. Basic aspects of pharmacodynamics and pharmacokinetics (PK) are investigated before approval for general prescription. READ MORE

  2. 2. Rational drug treatment in the elderly "To treat or not to treat"

    University dissertation from Örebro : Örebro universitet

    Author : Inger Nordin Olsson; Örebro universitet.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Elderly; polypharmacy; drug evaluation; nursing process; monitoring; inappropriate prescribing; quality of life; patient participation; Vårdvetenskap; Nursing Science;

    Abstract : The general aim of this thesis was to examine the effect of interventions on the usage of inappropriate and hazardous multi-medication in the elderly ≥75 years with ≥5 drugs.Methods: Paper I describes a cluster randomization of nursing homes, the outcomes were; number of drugs, health status and evaluations. READ MORE

  3. 3. Modeling the Interaction Space of Biological Macromolecules: A Proteochemometric Approach Applications for Drug Discovery and Development

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Aleksejs Kontijevskis; Uppsala universitet.; [2008]
    Keywords : Bioinformatics; proteochemometrics; bioinformatics; chemoinformatics; chemical space; QSAR; retroviral proteases; HIV-1; drug resistance; pharmacogenomics; cytochrome P450; GPCRs; melanocortin receptors; interactome; machine-learning; rough sets; Bioinformatik;

    Abstract : Molecular interactions lie at the heart of myriad biological processes. Knowledge of molecular recognition processes and the ability to model and predict interactions of any biological molecule to any chemical compound are the key for better understanding of cell functions and discovery of more efficacious medicines. READ MORE

  4. 4. Bioanalytical development for application in therapeutic drug monitoring : focus on drugs used in psychiatry

    University dissertation from Linköping : Linköpings universitet

    Author : Daniel Öhman; Linköpings universitet.; Linköpings universitet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE; MEDICIN;

    Abstract : Introduction: Since the 1950s and onwards, many new psychoactive drugs have been successfully introduced in clinical practice. A common feature of these drugs is a profound metabolism before clearance from the body. READ MORE

  5. 5. Real-Time Monitoring of Healthcare Interventions in Routine Care Effectiveness and Safety of Newly Introduced Medicines

    University dissertation from Uppsala : Uppsala University

    Author : Thomas Cars; Uppsala universitet.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Electronic Health Records; Comparative Effectiveness Research; Comparative Safety Research; Sequential drug monitoring; propensity score; real-world data; infliximab; TNF-inhibitors; dronedarone; amiodarone; flecainide; Farmakoepidemiologi; Pharmacoepidemiology;

    Abstract : Before market authorization of new medicines, their efficacy and safety are evaluated using randomized controlled trials. While there is no doubt about the scientific value of randomized trials, they are usually conducted in selected populations with questionable generalizability to routine care. READ MORE