Search for dissertations about: "drug permeation"

Showing result 1 - 5 of 11 swedish dissertations containing the words drug permeation.

2. 1. Refined in vitro Models for Prediction of Intestinal Drug Transport : Role of pH and Extracellular Additives in the Caco-2 Cell Model

   Author : Sibylle Neuhoff; Per Artursson; Anna-Lena Ungell; Patrick Augustijns; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; Caco-2 cells; membrane permeability; drug permeation; drug efflux ratios; drug uptake ratios; Cremophor EL; bovine serum albumin; pH-dependent permeability; drug transport; FARMACI; PHARMACY; FARMACI;

   Abstract : Drug transport across the intestinal epithelium is roughly predicted from permeability values obtained from Caco-2 cell monolayers. This thesis examines the important role of pH and extracellular additives for increasing the reliability and predictivity of the in vitro screening system, Caco-2. READ MORE

4. 2. Oral delivery of macromolecules formulated with permeation enhancers

   Author : Staffan Berg; Christel Bergström; Nigel Davies; Andreas Hugerth; David Brayden; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oral peptide delivery; permeation enhancer; sodium caprate; oral drug delivery; intestinal absorption of macromolecules; Biofarmaci; Biopharmaceutics; Galenisk farmaci; Pharmaceutics;

   Abstract : Therapeutic macromolecules including peptides, proteins, and nucleotide-based ones (such as antisense oligonucleotides and RNAs) have great potential as drug candidates. One drawback is that they typically need to be administered parenterally via subcutaneous, intramuscular or intravenous injections. READ MORE

5. 3. Predicting oral performance of lipid-based formulations using in vitro methods

   Author : Oliver Hedge; Christel Bergström; Frédéric Carriere; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lipid-based formulation s ; SEDDS; artificial membrane s ; cell monolayer s ; oral drug delivery; lipolysis; permeation; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : Oral administration of drugs is widely considered preferable to other methods by end-users and healthcare providers alike; however, not all drug compounds are inherently suited for it because some molecules are not well-absorbed by the intestine. Good absorption requires both dissolution and permeation. READ MORE

6. 4. Understanding the gastrointestinal mucus and its impact on drug absorption

   Author : Vicky Barmpatsalou; Christel Bergström; Eva Karlsson; Betty Lomstein Pedersen; Hanne Mørck Nielsen; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mucus; gastrointestinal; pigs; dogs; physiology; colonic; in vitro assay; drug diffusion; macromolecules;

   Abstract : The gastrointestinal mucus is a hydrogel lining the luminal side of the gastrointestinal epithelium. Mucus is vital for gut homeostasis because it protects the epithelium from the noxious external environment. READ MORE

7. 5. Advanced Methods for Evaluation of the Performance of Complex Drug Delivery System

   Author : Caroline Alvebratt; Christel Anna Sofia Bergström; Maria Strömme; Caitriona O'Driscoll; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amorphous solid dispersion; coadministration; digestion; dissolution; drug absorption; enabling formulation; in vitro assay; lipid-based formulation; mesoporous carrier; supersaturation; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : Low oral bioavailability of drugs originating from poor aqueous solubility is a common issue in drug development. Various enabling formulations have been presented to circumvent this limitation, many making use of supersaturation. In these, the drug is delivered to the gastro-intestinal lumen in a high energy state e.g. READ MORE