Search for dissertations about: "drug resistance"

Showing result 1 - 5 of 470 swedish dissertations containing the words drug resistance.

  1. 1. Circumventing drug resistance : Studies exploring the expediency of a total cell kill chemoresistance assay

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Bertil Jonsson; [1998]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical sciences; drug resistance; drug resistance assay; clinical correlations; cancer; human; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Abstract : Cellular resistance to anti-cancer drugs is considered to be the major cause of treatment failure in clinical practice. The present studies have therefore focused on ways to circumvent resistance as evaluated by an in vitro chemoresistance assay. READ MORE

  2. 2. Studies of Retroviral Reverse Transcriptase and Flaviviral Protease Enzymes as Antiviral Drug Targets Applications in Antiviral Drug Discovery & Therapy

    University dissertation from Acta Universitatis Upsaliensis : Uppsala universitet

    Author : Muhammad Junaid; Jarl ES Wikberg; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Virus; enzymes; HIV AIDS; retroviral reverse transcriptase; flaviviral protease; NRTIs; proteochemometrics; drug resistance; DEN; JEV; NS2B H -NS3pro; antiviral; drug targets; drug discovery; drug therapy.; Farmakologi; Pharmacology;

    Abstract : Viruses are a major threat to humans due to their unique adaptability, evolvability and  capability to control their hosts as parasites and genetic elements. HIV/AIDS is the third largest cause of death by infectious diseases in the world, and drug resistance due to the viral mutations is still the leading cause of treatment failure. READ MORE

  3. 3. Kinetic studies of NS3 and NS5B from Hepatitis C virus Implications and applications for drug discovery

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Göran Dahl; Helena Danielson; Raffaele De Francesco; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatitis C virus; NS3; NS5B; enzyme kinetics; inhibition; resistance; drug; MEDICINE Chemistry Biochemistry; MEDICIN Kemi Biokemi; Biokemi; Biochemistry;

    Abstract : The aim of these studies was to increase our understanding of the non-structural proteins 3 and 5B (NS3 and NS5B) from the hepatitis C virus (HCV), and thereby contribute to the development of new and better drugs against HCV.By studying NS3 with substitutions identified to be associated with resistance to NS3 inhibitors in clinical trials (R155Q, A156T and D168V) it was found that not all inhibitors were affected, indicating that cross-resistance can be avoided. READ MORE

  4. 4. Biosensor Studies of Ligand Interactions with Structurally Flexible Enzymes Applications for Antiviral Drug Development

    University dissertation from Uppsala : Institutionen för naturvetenskaplig biokemi

    Author : Matthis Geitmann; U. Helena Danielson; Marc H. V. van Regenmortel; [2005]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; SPR biosensor; HIV-1 reverse transcriptase; HCMV protease; interaction kinetics; drug discovery; non-nucleoside inhibitor; resistance; Biokemi; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi;

    Abstract : The use of a surface plasmon biosensor fills a missing link in kinetic studies of enzymes, since it measures directly the interaction between biomolecules and allows determination of parameters that are determined only indirectly in activity assays. The present thesis deals with kinetic and dynamic aspects of ligand binding to two viral enzymes: the human cytomegalovirus (HCMV) protease and the human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT). READ MORE

  5. 5. New Approaches to Studies of Paracellular Drug Transport in Intestinal Epithelial Cell Monolayers

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Staffan Tavelin; Per Artursson; Staffan Tavelin; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; intestinal epithelium; tight junctions; cell culture; Galenisk farmaci; PHARMACY Pharmaceutics; FARMACI Galenisk farmaci; galenisk farmaci; Pharmaceutics;

    Abstract : Studies of intestinal drug permeability have traditionally been performed in the colon-derived Caco-2 cell model. However, the permeability of these cell monolayers resembles that of the colon rather than that of the small intestine, which is the major site of drug absorption following oral administration. READ MORE