Search for dissertations about: "drug resistance"

Showing result 6 - 10 of 554 swedish dissertations containing the words drug resistance.

  2. 6. ASNA1 and cisplatin resistance : studies in C. elegans and in human tumor cells

    Author : Oskar Hemmingsson; Peter Naredi; Mef Nilbert; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ASNA1; Cisplatin; C. elegans; Drug resistance; Apoptosis; Surgery; Kirurgi; Oncology; Onkologi; Surgery; kirurgi; Oncology; onkologi; cellforskning; cell research;

    Abstract : Platinum based chemotherapy is widely used to treat cancer. Cisplatin (diamminedichloroplatinum) combination treatments provide cure for metastatic testicular cancer and prolong survival for patients suffering from ovarian, head and neck, bladder and non small cell lung cancer. READ MORE

  4. 7. Exploring Inhibitors of HIV-1 Protease : Interaction Studies with Applications for Drug Discovery

    Author : Maria T. Lindgren; Helena Danielson; Jozsef Tözser; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; kinetics; biosensors; ADME; drug discovery; SPR; resistance; inhibition; copper; Biokemi; Biochemistry; Biokemi;

    Abstract : A variety of HIV-1 protease inhibitors and their interactions with the enzyme have been characterized in order to identify novel and improved drugs against AIDS. The investigated inhibitors were represented by clinical and non-clinical inhibitors, active site and allosteric inhibitors, transition-state analogues and metal-ions. READ MORE

  5. 8. Heterogeneity of leukemic cells with regard to daunorubicin accumulation and efflux : potential role in drug resistance

    Author : Eva Knaust; Linköpings universitet; []
    Keywords : Drug resi stance. acute myeloid leukemia; flow cytometry; gene expression; transport kinetics; apoptosis; MEDICINE; MEDICIN;

    Abstract : Cellular resistance to chemotherapy is a major cause of treatment failure in acute myelocytic leukemia (AML) and other malignancies. Drug resistance is multifactorial; the most studied mechanism being multidrug resistance (MDR), mediated by the P-glycoprotein (PPG), a transmembrane transport protein with a pump function, encoded by the mdr 1 gene. READ MORE

  6. 9. Pharmacokinetic, efficacy and safety modeling of new treatments against drug-resistant tuberculosis

    Author : Lénaïg Tanneau; Mats Karlsson; Elin Svensson; Italo Poggesi; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; pharmacodynamics; pharmacometrics; nonlinear mixed effect models; tuberculosis; drug-resistance; bedaquiline; delamanid; metabolite; drug-drug interactions; QTc interval; transaminases; time-to-positivity; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Tuberculosis (TB) is an ancient infectious disease that remains one of the greatest killers on the planet. Its eradication is impeded by the development of resistance to first-line treatment. Each year half a million patients are infected with drug-resistant (DR) TB. READ MORE

  7. 10. Drug resistance in mycobacterium tuberculosis

    Author : Getahun Abate; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Multidrug-resistance; tuberculosis; cefepime; moxicillin-clavulanate; ethambutol; WIT; rifampicin; isoniazid; katG;

    Abstract : Drug-resistant tuberculosis is a global public health problem. This investigation was performed to find ways of improving regimens that could be used for the treatment of drug- and multidrug-resistant TB and also to find a rapid method of diagnosis of drug resistant TB, particularly MDR-TB. Among 107 isolates of M. READ MORE