Search for dissertations about: "drug sampling"
Showing result 1 - 5 of 93 swedish dissertations containing the words drug sampling.
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1. Drug Analysis : Bioanalytical Method Development and Validation
Abstract : This thesis describes bioanalytical methods for drug determination in biological matrixes, with drugs in focus used against diseases largely affecting low-income countries. Solid-phase extraction is used for sample cleanup, and processed samples are analyzed by liquid chromatography. READ MORE
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2. Sampling from molecular unnormalized distributions with Deep Generative Models
Abstract : This thesis investigates how Deep Generative Models (DGMs) can address important drug discovery problems involving sampling from unnormalized distributions. It consists of two papers focusing on this challenge’s aspects: molecular design and conformational sampling. READ MORE
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3. On the estimation of ligand binding affinities
Abstract : A method to accurately estimate the binding affinity of a small molecule to a receptor would be indispensable in numerous fields. For instance, most drugs exert their action by binding to a macromolecule target. Thus, a lot of time and resources could be saved in drug design by predicting affinities by computer programs. READ MORE
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4. Drug repositioning in chemoprevention of colorectal cancer
Abstract : BackgroundColorectal cancer (CRC) ranks as the third most frequently occurring cancer and the second leading cause of cancer-related deaths worldwide. In response to the high demand for an effective prevention strategy, chemoprevention, using medications to block the pathogenetic pathways of disease, might be an attractive strategy to offer a more effective option at a low cost. READ MORE
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5. Mistletoes and Thionins : as Selection Models in Natural Products Drug Discovery
Abstract : The process of drug discovery from natural products starts with the selection of study object. In this project recent knowledge and methods are incorporated to investigate the process of such selection for pharmacognostic investigations. READ MORE