Search for dissertations about: "drug sensitivity"

Showing result 1 - 5 of 316 swedish dissertations containing the words drug sensitivity.

  2. 1. Interaction Studies of Secreted Aspartic Proteases (Saps) from Candida albicans : Application for Drug Discovery

    Author : Dan Backman; Helena Danielson; Birgitta Tomkinson; Gunnar Henriksson; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; SPR Biosensor; Secreted aspartic proteases; Candida albicans; interaction kinetics; drug discovery; protease inhibitor; Biokemi; Biochemistry; Biokemi;

    Abstract : This thesis is focused on enzymatic studies of the secreted aspartic proteases (Saps) from Candida albicans as a tool for discovery of anti-candida drugs. C. albicans causes infections in a number of different locations, which differ widely in the protein substrates available and pH. Since C. READ MORE

  4. 2. Potentially inappropriate drug treatment among older people with cognitive impairment

    Author : Eva Sönnerstam; Maria Gustafsson; Maria Sjölander; Hugo Lövheim; Ylva Böttiger; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Older people; major neurocognitive disorder; cognitive impairment; potentially inappropriate medications; drug-drug interactions; renal function; adverse drug reactions; nursing homes; time trends; Clinical Pharmacology; klinisk farmakologi;

    Abstract : Background: The aging process contributes to alterations in organ systems, which lead to an increased risk for chronic conditions. Drug treatment is an important strategy in the management of chronic conditions; however, pharmacokinetic and pharmacodynamic alterations contribute to increased sensitivity to drug effects. READ MORE

  5. 3. Drug Repositioning for Cancer Treatment : Novel Candidate Identification Strategies

    Author : Madiha Nazir; Mårten Fryknäs; Sigurd Vitols; Uppsala universitet; []
    Keywords : cancer treatment; drug repositioning; Phosphodiesterase 3A PDE3A ; apoptosis; combination screening;

    Abstract : Regardless of the enormous investments in cancer research and drug development, the proportion of approved drugs in oncology is low compared to other indications, and new avenues are needed. One attractive approach in this regard is drug repositioning where new uses outside the scope of the original medical indications for existing drugs are identified. READ MORE

  6. 4. In Vitro Drug Sensitivity and Apoptosis in Chronic Lymphocytic Leukemia

    Author : Maria Norberg; Richard Rosenquist; Anna Åleskog; Elin Lindhagen; Gerard Tobin; Per-Ola Andersson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chronic lymphocytic leukemia; in vitro drug sensitivity; apoptosis; prognostic markers; Clinical genetics; Klinisk genetik; Haematology; Hematologi; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; MEDICINE; MEDICIN; Medical genetics; Medicinsk genetik; Medical Science; Medicinsk vetenskap; Clinical Genetics; Klinisk genetik; Molekylär genetik; Molecular Genetics; Medical Genetics; Medicinsk genetik; Molekylär medicin; Molecular Medicine;

    Abstract : Chronic lymphocytic leukemia (CLL) is a heterogeneous malignancy displaying varying clinical outcome, where molecular markers today can divide patients into prognostic subgroups. Despite the introduction of new agents for treatment, remissions are usually not sustained in CLL and resistance towards treatment can partly be explained by aberrant apoptosis. READ MORE

  7. 5. Physicochemical and Biopharmaceutical Characterisation of Small Drug Molecules by Capillary Electrophoresis

    Author : Eivor Örnskov; Staffan Folestad; Karin E. Markides; Morteza Khaledi; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; capillary electrophoresis CE ; micellar electrokinetic chromatography MEKC ; drug; liposome; microemulsion; coating; pKa; lipophilicity; multivariate analysis; molecular descriptor; hierarchical analysis; passiv absorption; Analytisk kemi; Analytical chemistry; Analytisk kemi;

    Abstract : Capillary Electrophoresis (CE) was explored as a means for physicochemical and biopharmaceutical characterisation of small drug molecules. Special attention was paid to the characterisation of acid-base and lipophilic properties of drug compounds by analysing their migration behaviour in different CE systems. READ MORE